Saganic Laura, Carr Jason, Solorio Rosa, Courogen Maria, Jaenicke Tom, Duerr Ann
Department of Health Services and Epidemiology, University of Washington, Seattle, WA 98195, USA.
AIDS Res Treat. 2012;2012:182672. doi: 10.1155/2012/182672. Epub 2011 Nov 15.
As more US HIV surveillance programs routinely use late HIV diagnosis to monitor and characterize HIV testing patterns, there is an increasing need to standardize how late HIV diagnosis is measured. In this study, we compared two measures of late HIV diagnosis, one based on time between HIV and AIDS, the other based on initial CD4(+) results. Using data from Washington's HIV/AIDS Reporting System, we used multivariate logistic regression to identify predictors of late HIV diagnosis. We also conducted tests for trend to determine whether the proportion of cases diagnosed late has changed over time. Both measures lead us to similar conclusions about late HIV diagnosis, suggesting that being male, older, foreign-born, or heterosexual increase the likelihood of late HIV diagnosis. Our findings reaffirm the validity of a time-based definition of late HIV diagnosis, while at the same time demonstrating the potential value of a lab-based measure.
随着越来越多的美国艾滋病病毒监测项目常规使用艾滋病病毒晚期诊断来监测和描述艾滋病病毒检测模式,对如何衡量艾滋病病毒晚期诊断进行标准化的需求日益增加。在本研究中,我们比较了两种艾滋病病毒晚期诊断的衡量方法,一种基于艾滋病病毒感染与艾滋病发病之间的时间,另一种基于初始CD4(+)结果。利用华盛顿州艾滋病病毒/艾滋病报告系统的数据,我们使用多变量逻辑回归来确定艾滋病病毒晚期诊断的预测因素。我们还进行了趋势检验,以确定晚期诊断病例的比例是否随时间发生了变化。两种方法都使我们对艾滋病病毒晚期诊断得出了相似的结论,表明男性、年龄较大、外国出生或异性恋会增加艾滋病病毒晚期诊断的可能性。我们的研究结果重申了基于时间的艾滋病病毒晚期诊断定义的有效性,同时也证明了基于实验室检测方法的潜在价值。