Department of Internal Medicine, Kitasato Medical Center Hospital, Kitasato University, Saitama.
Int J Gen Med. 2011;4:793-8. doi: 10.2147/IJGM.S25822. Epub 2011 Nov 23.
This report describes a case showing histologic features of acute cholangitis with an over-the-counter drug. A 48-year-old woman was diagnosed with general malaise and progressive jaundice. A thorough review of her medical history revealed that the patient had taken an over-the-counter drug, Pabron Gold(®), which she had used previously, that may have caused liver injury. Laboratory investigations revealed jaundice and liver dysfunction. Endoscopic retrograde cholangiography detected no extrahepatic biliary duct dilatation or stones. Liver biopsy indicated acute cholangitis involving neutrophils and eosinophils. Electron microscopy revealed fragmented nuclei, indicating that the degenerative bile duct-related epithelial cells were in an apoptotic process.
本报告描述了一例与非处方药物相关的急性胆管炎的组织学特征。一名 48 岁女性因全身不适和进行性黄疸就诊。详细回顾其病史发现，患者曾使用过一种名为 Pabron Gold(®)的非处方药物，可能导致了肝损伤。实验室检查发现黄疸和肝功能异常。内镜逆行胰胆管造影未发现肝外胆管扩张或结石。肝活检提示急性胆管炎伴中性粒细胞和嗜酸性粒细胞浸润。电子显微镜显示核碎裂，表明与胆汁淤积相关的胆管上皮细胞处于凋亡过程中。
