先进脂蛋白检测在糖尿病中的临床应用
Clinical applications of advanced lipoprotein testing in diabetes mellitus.
作者信息
Moin Danyaal S, Rohatgi Anand
机构信息
Department of Internal Medicine, University of Texas-Southwestern Medical Center, Dallas, TX, USA.
出版信息
Clin Lipidol. 2011 Aug 1;6(4):371-387. doi: 10.2217/clp.11.37.
Abstract
Traditional lipid profiles often fail to fully explain the elevated cardiovascular risk of individuals with diabetes mellitus. Advanced lipoprotein testing offers a novel means to evaluate dyslipidemia and refine risk estimation. Numerous observational studies have demonstrated a characteristic pattern of elevated levels of small, dense LDL particles, out of proportion to traditional lipid levels, in patients with both diabetes mellitus and the metabolic syndrome. Commonly used glucose and lipid-lowering agents have varied effects in patients with diabetes on both LDL and HDL subfractions. The exact role of advanced lipoprotein testing in patients with diabetes mellitus and the metabolic syndrome remains unclear but may offer improved assessment of cardiovascular risk compared with traditional lipid measurements.
摘要
传统的血脂谱常常无法充分解释糖尿病患者心血管风险升高的情况。先进的脂蛋白检测提供了一种评估血脂异常和完善风险评估的新方法。大量观察性研究表明，糖尿病和代谢综合征患者存在一种特征性模式，即小而密的低密度脂蛋白颗粒水平升高，与传统血脂水平不成比例。常用的降糖和降脂药物对糖尿病患者的低密度脂蛋白和高密度脂蛋白亚组分有不同影响。先进的脂蛋白检测在糖尿病和代谢综合征患者中的具体作用尚不清楚，但与传统血脂测量相比，可能能更好地评估心血管风险。
相似文献
1
Clinical applications of advanced lipoprotein testing in diabetes mellitus.先进脂蛋白检测在糖尿病中的临床应用
Clin Lipidol. 2011 Aug 1;6(4):371-387. doi: 10.2217/clp.11.37.
2
Beyond low-density lipoprotein: addressing the atherogenic lipid triad in type 2 diabetes mellitus and the metabolic syndrome.超越低密度脂蛋白：应对2型糖尿病和代谢综合征中的致动脉粥样硬化脂质三联征。
Am J Cardiovasc Drugs. 2005;5(6):379-87. doi: 10.2165/00129784-200505060-00005.
3
Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey.冠心病的一级预防：新数据整合、观点演变、目标修订以及瑞舒伐他汀在管理中的作用。一项全面综述。
Drug Des Devel Ther. 2011;5:325-80. doi: 10.2147/DDDT.S14934. Epub 2011 Jun 13.
4
Diabetic dyslipidemia.糖尿病血脂异常
Am J Cardiol. 1998 Dec 17;82(12A):67U-73U; discussion 85U-86U. doi: 10.1016/s0002-9149(98)00848-0.
5
Lipoprotein Subfractions and Glucose Homeostasis in Prediabetes and Diabetes in Taiwan.脂蛋白亚组分与台湾地区糖尿病前期和糖尿病患者的血糖稳态
J Atheroscler Thromb. 2019 Oct 1;26(10):890-914. doi: 10.5551/jat.48330. Epub 2019 Feb 7.
6
Does Adopting Western Low-density Lipoprotein Cholesterol Targets Expose Indians to a Higher Risk of Cardiovascular Events? Expert Opinion From the Lipid Association of India.采用西方低密度脂蛋白胆固醇目标是否会使印度人面临更高的心血管事件风险？来自印度脂质协会的专家意见。
J Assoc Physicians India. 2024 Oct;72(10):71-76. doi: 10.59556/japi.72.0692.
7
Discordance between serum cholesterol concentration and atherogenic lipoprotein particle number in people with metabolic disease: A systematic review.代谢疾病患者血清胆固醇浓度与致动脉粥样硬化脂蛋白颗粒数量之间的不一致性：一项系统评价。
Diabetes Obes Metab. 2025 Jun;27(6):2940-2954. doi: 10.1111/dom.16335. Epub 2025 Mar 16.
8
A new perspective in the treatment of dyslipidemia : can fenofibrate offer unique benefits in the treatment of type 2 diabetes mellitus?血脂异常治疗的新视角：非诺贝特在2型糖尿病治疗中能带来独特益处吗？
Treat Endocrinol. 2005;4(5):311-7. doi: 10.2165/00024677-200504050-00004.
10
Analysis of Lipoprotein Subfractions in 920 Patients With and Without Type 2 Diabetes.920例2型糖尿病患者与非2型糖尿病患者的脂蛋白亚组分分析
Heart Lung Circ. 2017 Mar;26(3):211-218. doi: 10.1016/j.hlc.2016.10.020. Epub 2016 Dec 9.
引用本文的文献
1
Exploring the Health Benefits and Therapeutic Potential of Roselle (Hibiscus sabdariffa) in Human Studies: A Comprehensive Review.探索玫瑰茄（木槿属）在人体研究中的健康益处和治疗潜力：一项综合综述。
Cureus. 2023 Nov 23;15(11):e49309. doi: 10.7759/cureus.49309. eCollection 2023 Nov.
2
Impact of a 2-year trial of nutritional ketosis on indices of cardiovascular disease risk in patients with type 2 diabetes.营养性生酮状态对 2 型糖尿病患者心血管疾病风险指标的影响：2 年试验结果
Cardiovasc Diabetol. 2020 Dec 8;19(1):208. doi: 10.1186/s12933-020-01178-2.
3
Squeezing lipids: NMR characterization of lipoprotein particles under pressure.挤压脂质：压力下脂蛋白颗粒的 NMR 特征分析。
Chem Phys Lipids. 2020 May;228:104874. doi: 10.1016/j.chemphyslip.2020.104874. Epub 2020 Jan 21.
4
Liposcale: a novel advanced lipoprotein test based on 2D diffusion-ordered 1H NMR spectroscopy.脂质谱：一种基于二维扩散排序氢核磁共振波谱的新型先进脂蛋白检测方法。
J Lipid Res. 2015 Mar;56(3):737-746. doi: 10.1194/jlr.D050120. Epub 2015 Jan 7.
5
The role of advanced lipid testing in the prediction of cardiovascular disease.高级血脂检测在心血管疾病预测中的作用。
Curr Atheroscler Rep. 2014 Mar;16(3):394. doi: 10.1007/s11883-013-0394-9.
本文引用的文献
1
Clinical implications of discordance between low-density lipoprotein cholesterol and particle number.载脂蛋白 B 与载脂蛋白 B 颗粒数对 LDL 胆固醇水平的影响。
J Clin Lipidol. 2011 Mar-Apr;5(2):105-13. doi: 10.1016/j.jacl.2011.02.001.
2
HDL measures, particle heterogeneity, proposed nomenclature, and relation to atherosclerotic cardiovascular events.高密度脂蛋白（HDL）的检测、颗粒异质性、建议的命名法，以及与动脉粥样硬化性心血管事件的关系。
Clin Chem. 2011 Mar;57(3):392-410. doi: 10.1373/clinchem.2010.155333. Epub 2011 Jan 25.
3
HDL 2 particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients.高密度脂蛋白 2 颗粒与 2 型糖尿病患者的高血糖、PON1 活性降低和氧化应激有关。
Clin Biochem. 2010 Oct;43(15):1230-5. doi: 10.1016/j.clinbiochem.2010.08.005. Epub 2010 Aug 13.
4
Ezetimibe alone or in combination with simvastatin increases small dense low-density lipoproteins in healthy men: a randomized trial.依泽替米贝单用或与辛伐他汀合用增加健康男性的小而密低密度脂蛋白：一项随机试验。
Eur Heart J. 2010 Jul;31(13):1633-9. doi: 10.1093/eurheartj/ehq181. Epub 2010 Jun 6.
5
Weight loss, glycemic control, and changes in cardiovascular biomarkers in patients with type 2 diabetes receiving incretin therapies or insulin in a large cohort database.在大型队列数据库中，接受肠促胰岛素治疗或胰岛素治疗的 2 型糖尿病患者的体重减轻、血糖控制和心血管生物标志物变化。
Diabetes Care. 2010 Aug;33(8):1759-65. doi: 10.2337/dc09-2062. Epub 2010 May 11.
6
The effects of ezetimibe and/or orlistat on triglyceride-rich lipoprotein metabolism in obese hypercholesterolemic patients.依泽替米贝和/或奥利司他对肥胖高胆固醇血症患者富含甘油三酯脂蛋白代谢的影响。
Lipids. 2010 May;45(5):445-50. doi: 10.1007/s11745-010-3409-0. Epub 2010 Apr 9.
7
Effect of pioglitazone on various parameters of insulin resistance including lipoprotein subclass according to particle size by a gel-permeation high-performance liquid chromatography in newly diagnosed patients with type 2 diabetes.在新诊断的 2 型糖尿病患者中，通过凝胶渗透高效液相色谱法，观察吡格列酮对脂蛋白亚类按颗粒大小划分的各种胰岛素抵抗参数的影响。
Endocr J. 2010;57(5):423-30. doi: 10.1507/endocrj.k10e-006. Epub 2010 Feb 17.
8
Beyond low-density lipoprotein cholesterol: respective contributions of non-high-density lipoprotein cholesterol levels, triglycerides, and the total cholesterol/high-density lipoprotein cholesterol ratio to coronary heart disease risk in apparently healthy men and women.除了低密度脂蛋白胆固醇之外：非高密度脂蛋白胆固醇水平、甘油三酯以及总胆固醇/高密度脂蛋白胆固醇比值对貌似健康的男性和女性冠心病风险的各自影响。
J Am Coll Cardiol. 2009 Dec 29;55(1):35-41. doi: 10.1016/j.jacc.2009.07.057.
9
The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice.胰高血糖素样肽 1 受体是仓鼠和小鼠餐后脂蛋白合成和分泌所必需的。
Diabetologia. 2010 Mar;53(3):552-61. doi: 10.1007/s00125-009-1611-5. Epub 2009 Dec 3.
10
Atorvastatin treatment lowers fasting remnant-like particle cholesterol and LDL subfraction cholesterol without affecting LDL size in type 2 diabetes mellitus: Relevance for non-HDL cholesterol and apolipoprotein B guideline targets.阿托伐他汀治疗可降低2型糖尿病患者的空腹残粒样颗粒胆固醇和低密度脂蛋白亚组分胆固醇，而不影响低密度脂蛋白大小：与非高密度脂蛋白胆固醇和载脂蛋白B指南目标的相关性。
Biochim Biophys Acta. 2010 Jan;1801(1):89-94. doi: 10.1016/j.bbalip.2009.09.021. Epub 2009 Oct 2.
Zotero 插件