Kazui Hiroaki, Yoshida Tetsuhiko, Takaya Masahiko, Sugiyama Hiromichi, Yamamoto Daisuke, Kito Yumiko, Wada Tamiki, Nomura Keiko, Yasuda Yuka, Yamamori Hidenaga, Ohi Kazutaka, Fukumoto Motoyuki, Iike Naomi, Iwase Masao, Morihara Takashi, Tagami Shinji, Shimosegawa Eku, Hatazawa Jun, Ikeda Yoshiyuki, Uchida Eiichi, Tanaka Toshihisa, Kudo Takashi, Hashimoto Ryota, Takeda Masatoshi
Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Dement Geriatr Cogn Dis Extra. 2011 Jan;1(1):20-30. doi: 10.1159/000323561. Epub 2011 Jan 6.
We compared indices of the revised version of the Wechsler Memory Scale (WMS-R) and scaled scores of the five subtests of the revised version of the Wechsler Adult Intelligence Scale (WAIS-R) in 30 elderly schizophrenia (ES) patients and 25 Alzheimer's disease (AD) patients in the amnestic mild cognitive impairment (aMCI) stage (AD-aMCI). In the WMS-R, attention/concentration was rated lower and delayed recall was rated higher in ES than in AD-aMCI, although general memory was comparable in the two groups. In WAIS-R, digit symbol substitution, similarity, picture completion, and block design scores were significantly lower in ES than in AD-aMCI, but the information scores were comparable between the two groups. Delayed recall and forgetfulness were less impaired, and attention, working memory and executive function were more impaired in ES than in AD-aMCI. These results should help clinicians to distinguish ES combined with AD-aMCI from ES alone.
我们比较了30例老年精神分裂症（ES）患者和25例处于遗忘型轻度认知障碍（aMCI）阶段的阿尔茨海默病（AD）患者（AD-aMCI）的韦氏记忆量表修订版（WMS-R）指标以及韦氏成人智力量表修订版（WAIS-R）五个子测验的量表分数。在WMS-R中，尽管两组的总体记忆相当，但ES组的注意力/集中力得分低于AD-aMCI组，而延迟回忆得分高于AD-aMCI组。在WAIS-R中，ES组的数字符号替换、相似性、图片完成和积木设计得分显著低于AD-aMCI组，但两组的信息得分相当。与AD-aMCI组相比，ES组的延迟回忆和遗忘受损较轻，而注意力、工作记忆和执行功能受损更严重。这些结果应有助于临床医生将合并AD-aMCI的ES与单纯ES区分开来。
