Kirkpatrick Brian, Messias Erick, Harvey Philip D, Fernandez-Egea Emilio, Bowie Christopher R
Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA, USA.
Schizophr Bull. 2008 Nov;34(6):1024-32. doi: 10.1093/schbul/sbm140. Epub 2007 Dec 21.
Schizophrenia is associated with a number of anatomical and physiological abnormalities outside of the brain, as well as with a decrease in average life span estimated at 20% in the United States. Some studies suggest that this increased mortality is not entirely due to associated causes such as suicide and the use of psychotropic medications. In this article, in order to focus greater attention on the increased mortality associated with schizophrenia, we present a special case of the hypothesis that physiological abnormalities associated with schizophrenia make a contribution to the increased mortality of schizophrenia: specifically, the hypothesis that schizophrenia is a syndrome of accelerated aging. Evidence consistent with this hypothesis comes from several areas. The biological plausibility of the hypothesis is supported by the existence of established syndromes of accelerated aging and by the sharing of risk factors between schizophrenia and other age-related conditions. We propose methods for testing the hypothesis.
精神分裂症与大脑之外的许多解剖学和生理学异常有关，在美国，其平均寿命估计减少了20%。一些研究表明，这种死亡率的增加并不完全归因于自杀和使用精神药物等相关原因。在本文中，为了更关注与精神分裂症相关的死亡率增加问题，我们提出了一个特殊案例假设，即与精神分裂症相关的生理异常导致了精神分裂症死亡率的增加：具体而言，就是精神分裂症是一种加速衰老综合征的假设。与该假设相符的证据来自多个领域。该假设的生物学合理性得到了已确定的加速衰老综合征的存在以及精神分裂症与其他与年龄相关病症之间风险因素共享的支持。我们提出了检验该假设的方法。
