一种间断的乌吉反应能够用于制备取代吲哚酚和氨基吲哚。
An interrupted Ugi reaction enables the preparation of substituted indoxyls and aminoindoles.
作者信息
Schneekloth John S, Kim Jimin, Sorensen Erik J
机构信息
Department of Chemistry, Princeton University, Frick Chemical Laboratory, Princeton NJ 08544.
出版信息
Tetrahedron. 2009 Apr 18;65(16):3096-3101. doi: 10.1016/j.tet.2008.08.055.
Abstract
In a variation of the classical Ugi reaction, an acid promoted reaction between imines and isocyanides forms both 3-aminoindoles and substituted indoxyls. A recently reported triflyl phosphoramide is shown to be critical to obtain high yields under mild conditions.
摘要
在经典乌吉反应的一种变体中，亚胺与异腈之间的酸促进反应生成了3-氨基吲哚和取代吲哚酚。最近报道的三氟甲磺酸磷酰胺被证明对于在温和条件下获得高产率至关重要。
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