Energy-rich glyceric acid oxygen esters: implications for the origin of glycolysis.

The apparent Gibbs free energy change of hydrolysis (delta G degrees', pH 7) of the 2- and 3-O-glyceroyl esters of 2- and 3-O-L-glyceroyl-L-glyceric acid methyl ester were measured at 25 degrees C. The 2- and 3-glyceroyl esters were found to be 'energy-rich' with delta G degrees' values of -9.1 kcal mol-1 and -7.8 kcal mol, respectively. This result indicates that the analogous 2- and 3-glyceroyl esters of polyglyceric acid are also 'energy-rich' and, therefore, could have acted as an energy source for primitive phosphoanhydride synthesis.