Centro de Investigación Biomédica de Occidente, Guadalajara, Jalisco 44340, Mexico.
Neural Plast. 2012;2012:309494. doi: 10.1155/2012/309494. Epub 2011 Nov 2.
Some selective estrogen receptor modulators, such as raloxifene and tamoxifen, are neuroprotective and reduce brain inflammation in several experimental models of neurodegeneration. In addition, raloxifene and tamoxifen counteract cognitive deficits caused by gonadal hormone deprivation in male rats. In this study, we have explored whether raloxifene and tamoxifen may regulate the number and geometry of dendritic spines in CA1 pyramidal neurons of the rat hippocampus. Young adult male rats were injected with raloxifene (1 mg/kg), tamoxifen (1 mg/kg), or vehicle and killed 24 h after the injection. Animals treated with raloxifene or tamoxifen showed an increased numerical density of dendritic spines in CA1 pyramidal neurons compared to animals treated with vehicle. Raloxifene and tamoxifen had also specific effects in the morphology of spines. These findings suggest that raloxifene and tamoxifen may influence the processing of information by hippocampal pyramidal neurons by affecting the number and shape of dendritic spines.
一些选择性雌激素受体调节剂，如雷洛昔芬和他莫昔芬，具有神经保护作用，并可减少几种神经退行性变实验模型中的脑炎症。此外，雷洛昔芬和他莫昔芬可逆转雄性大鼠性腺激素剥夺引起的认知缺陷。在这项研究中，我们探讨了雷洛昔芬和他莫昔芬是否可以调节大鼠海马 CA1 锥体神经元树突棘的数量和几何形状。年轻成年雄性大鼠注射雷洛昔芬（1mg/kg）、他莫昔芬（1mg/kg）或载体，并在注射后 24 小时处死。与用载体处理的动物相比，用雷洛昔芬或他莫昔芬处理的动物的 CA1 锥体神经元中的树突棘数量密度增加。雷洛昔芬和他莫昔芬对棘突的形态也有特定的影响。这些发现表明，雷洛昔芬和他莫昔芬可能通过影响树突棘的数量和形状来影响海马锥体神经元的信息处理。
