Reproductive Medicine Unit, Hera Association, Catania, Italy.
Eur Rev Med Pharmacol Sci. 2011 Oct;15(10):1212-4.
Polycystic ovary syndrome (PCOS) is a multifactorial syndrome affecting 10% of women in reproductive age. Insulin sensitizer agents are the best therapeutic option for PCOS patients; among which there is Inositol. Inositol is a polyalcohol existing as nine different stereoisomers, two of which have been shown to be insulin mediators: myo-inositol (MI) and D-chiro-inositol (DCI). So far only MI have been show to be present in the follicular fluid and in a direct comparison between MI and DCI only MI was able to improve oocyte and embryo quality. Therefore, Could we say "bye-bye D-chiro-Inositol" in the practice of clinical gynecology and reproductive medicine?
多囊卵巢综合征（PCOS）是一种影响 10%生殖年龄女性的多因素综合征。胰岛素增敏剂是 PCOS 患者的最佳治疗选择；其中有肌醇。肌醇是一种存在 9 种不同立体异构体的多醇，其中两种已被证明是胰岛素调节剂：肌醇（MI）和 D-手性肌醇（DCI）。到目前为止，只有 MI 被发现在卵泡液中，并且在 MI 和 DCI 之间的直接比较中，只有 MI 能够改善卵母细胞和胚胎质量。因此，我们是否可以在临床妇科和生殖医学实践中说“再见 D-手性肌醇”？
