Hawass N D, el Badawi M G, Fatani J A, al-Meshari A, Makanjoula D, Edress Y B
Department of Radiology, King Saud University Hospital, Kingdom of Saudi Arabia.
Pediatr Radiol. 1990;20(7):528-35. doi: 10.1007/BF02011383.
Thirty-three cases of 1,500 spontaneously-aborted foetuses showed hepatic calcifications. The exact location of these calcifications were confirmed by contrast studies, anatomic dissection, and further histology when necessary. Of them, 18 were calcified hepatic vein thrombi (CHVT), 12 were calcified portal vein thrombi (CPVT), 2 were parenchymal calcifications, and one was mixed. Associated anomalies were high (85% of cases). No significant difference was found between the type and percentage of anomalies of those with CHVT and those with CPVT. The most common anomalies encountered in all cases were meconium intraluminal calcification (27%), cystic hygroma (18%), and metaphyseal defect (18%). In view of this, it is suggested that a variety of severe foetal illnesses predispose to CHVT and CPVT. At correlation with maternal factors, it was found that the highest incidence was in the third decade. A significant high percentage of mothers (33%) had been on contraceptive pills, and there was interesting inverse relationship of hepatic calcification with gravidity. Practically, it is also hoped that the awareness of the presence of various types of hepatic calcifications will help in their detection prenatally by ultrasound.
在1500例自然流产胎儿中，有33例出现肝脏钙化。通过造影检查、解剖 dissection以及必要时的进一步组织学检查确定了这些钙化的具体位置。其中，18例为肝静脉钙化血栓（CHVT），12例为门静脉钙化血栓（CPVT），2例为实质钙化，1例为混合型。相关畸形发生率较高（85%的病例）。CHVT患者和CPVT患者的畸形类型和百分比之间未发现显著差异。所有病例中最常见的畸形是胎粪腔内钙化（27%）、囊状水瘤（18%）和干骺端缺损（18%）。鉴于此，提示多种严重胎儿疾病易导致CHVT和CPVT。与母亲因素相关分析发现，发病率最高的是在第三个十年。相当高比例的母亲（33%）曾服用避孕药，并且肝脏钙化与妊娠次数存在有趣的负相关关系。实际上，也希望对各种类型肝脏钙化的认识有助于产前通过超声检测到它们。
