Comba P, Fazzo L, Fusco M, Benedetti M, Pirastu R, Ricci P
Dipartimento ambiente e connessa prevenzione primaria, Istituto superiore di sanità, Rome.
Epidemiol Prev. 2011 Sep-Dec;35(5-6 Suppl 4):189-91.
Cancer incidence is an outcome of interest in studies assessing the health impact of polluted sites, for which an example is represented by SENTIERI Project. Incidence data are characterized by better diagnostic quality and are not influenced by survival factors, furthermore they allow the investigation of high-survival neoplasms (i.e. childhood cancer) and rare malignancies. Furthermore, the study of incidence is more informative than mortality for non-lethal tumours, therefore it represents an advancement in respect to the study of mortality completed in SENTIERI Project. In the last decade in Italy some environmental epidemiology studies used cancer register data, for example the Biancavilla (Sicily) investigation on fluoro-edenite related mesothelioma and the study in an area of Naples Province where hazardous waste was extensively dumped. In this frame, ISS planned some collaborative studies with Siracusa, Mantua and Ferrara cancer Registries, where three major polluted sites are located. Following these pilot studies an ISS-AIRTUM (Italian Association of Cancer Registries) collaborative study has been planned. For a description of SENTIERI, refer to the 2010 supplement of Epidemiology & Prevention, devoted to the Project.
癌症发病率是评估污染场地对健康影响的研究中一个重要的研究结果,SENTIERI项目就是这类研究的一个例子。发病率数据具有更好的诊断质量,且不受生存因素的影响,此外,它还能用于研究高生存率的肿瘤(如儿童癌症)和罕见恶性肿瘤。此外,对于非致命性肿瘤,发病率研究比死亡率研究更具信息量,因此相对于SENTIERI项目中完成的死亡率研究而言,它是一个进步。在过去十年中,意大利的一些环境流行病学研究使用了癌症登记数据,例如比安卡维拉(西西里岛)关于氟透辉石相关间皮瘤的调查,以及那不勒斯省一个危险废物大量倾倒地区的研究。在此背景下,意大利国家卫生研究院(ISS)计划与锡拉库萨、曼图亚和费拉拉癌症登记处开展一些合作研究,这三个地方都有主要的污染场地。在这些试点研究之后,意大利国家卫生研究院(ISS)与意大利癌症登记协会(AIRTUM)计划开展一项合作研究。关于SENTIERI项目的描述,请参考2010年《流行病学与预防》的增刊,该增刊专门介绍了该项目。