Baranowska Boguslawa, Kochanowski Jan, Grudniak Mariusz, Baranowska-Bik Agnieszka, Wolinska-Witort Ewa, Martynska Lidia, Bik Wojciech
Neuroendocrinology Department, Medical Centre of Postgraduate Education, Warsaw, Poland.
Neuro Endocrinol Lett. 2011;32(5):711-5.
An association between cerebral infarct risk factors and serum adiponectin levels (both total and separate isoforms) has previously been identified. The aim of this study was to assess circulating levels of all forms of adiponectin in the course of an ischemic stroke.
Adiponectin and its isoforms (HMW, MMW and LMW) were measured in serum samples taken from 38 women in the first 24 hours of cerebral infarct and 38 controls matched for gender, body mass index (BMI) and age. In addition, biochemical parameters (glucose, insulin, lipid profile) and clinical data (blood pressure, weight, and height) were evaluated.
A significant reduction in serum levels of adiponectin and all examined fractions of this adipokine was observed in women suffering from acute ischemic stroke, compared with the matched controls.
Differences in the serum adiponectin array between stroke subjects and controls were identified and further studies are required to investigate the clinical implications of this finding.
先前已确定脑梗死危险因素与血清脂联素水平（包括总脂联素和不同亚型）之间存在关联。本研究旨在评估缺血性卒中过程中各种形式脂联素的循环水平。
在脑梗死后最初24小时内采集的38名女性血清样本以及38名性别、体重指数（BMI）和年龄相匹配的对照者血清样本中，检测脂联素及其亚型（高分子量、中分子量和低分子量）。此外，还评估了生化参数（血糖、胰岛素、血脂谱）和临床数据（血压、体重和身高）。
与匹配的对照组相比，急性缺血性卒中女性患者血清脂联素水平及其所有检测部分均显著降低。
已确定卒中患者与对照组血清脂联素谱存在差异，需要进一步研究以探讨这一发现的临床意义。
