Han Qian, Shu Zunhua, Liang Xuemei, Mi Rui, Yang Lei, Li Peng
Department of Internal Neurology, Tianjin 4th Central Hospital Tianjin 300140, China.
Department of Medical Affairs, Affiliated Hospital of Changchun University of Traditional Chinese Medicine Changchun 130021, China.
Int J Clin Exp Med. 2015 Sep 15;8(9):16719-23. eCollection 2015.
Previous study suggested adiponectin receptor 2 (ADIPOR2) genetic polymorphisms were associated with the risk of ischemic stroke. However, the relation between adiponectin receptor 1 (ADIPOR1) gene polymorphism and stroke remains unclear.
In the present study, we utilized the polymerase chain reaction-sequencing method to detect rs2275737 and s1342387 genotypes of ADIPOR1 gene in 300 cases of ischemic stroke patients and 300 age- and sex- matched healthy controls.
For rs2275737, we found A allele carriers have increased risk to ischemic stroke (OR=2.570, 95% CI: 1.999-3.305); also, we found rs1342387 A allele was associated with the risk for stroke (OR=1.351, 95% CI: 1.074-1.699). After adjusted for confounders such as hypertension, diabetes, and smoking, we found the association remains significant.
ADIPOR1 genetic polymorphism may increase the risk of ischemic stroke.
先前的研究表明脂联素受体2（ADIPOR2）基因多态性与缺血性中风风险相关。然而，脂联素受体1（ADIPOR1）基因多态性与中风之间的关系仍不清楚。
在本研究中，我们利用聚合酶链反应测序方法检测了300例缺血性中风患者及300例年龄和性别匹配的健康对照者中ADIPOR1基因的rs2275737和s1342387基因型。
对于rs2275737，我们发现携带A等位基因者患缺血性中风的风险增加（OR = 2.570，95%CI：1.999 - 3.305）；此外，我们发现rs1342387的A等位基因与中风风险相关（OR = 1.351，95%CI：1.074 - 1.699）。在对高血压、糖尿病和吸烟等混杂因素进行校正后，我们发现这种关联仍然显著。
ADIPOR1基因多态性可能增加缺血性中风的风险。
