多体素磁共振波谱分析：右侧额叶旁矢状窦旁皮质——神经生化性别差异区域？
Multivoxel MRS: right frontal parafalcine cortex - area of neurobiochemical gender differentiation?
作者信息
Ostojic Jelena, Kozic Dusko, Lucic Milos, Konstantinovic Jasmina, Covickovic-Sternic Nadezda, Pavlovic Aleksandra, Bogdanovic-Stojanovic Dragana, Semnic Robert
机构信息
Institute of Oncology Sremska Kamenica, University of Novi Sad School of Medicine, Sremska Kamenica, Serbia.
出版信息
Neuro Endocrinol Lett. 2011;32(5):683-7.
OBJECTIVE
To determine the presence of gender neurometabolic differences in healthy men and women by multivoxel magnetic resonance spectroscopy (MRS).
MATERIALS AND METHODS
We performed multivoxel magnetic resonance imaging and spectroscopy in 50 healthy volunteers (27 women and 23 men) using 1.5T scanner. Spectra from 12 different voxels were obtained, covering frontal, paracentral, and parietal white and gray matter. Three dominant signals were analyzed: NAA, tCr and Cho, and expressed as ratios of Cho/tCr, NAA/tCr, NAA/Cho.
RESULTS
There was statistically significant gender difference between Cho/Cr and NAA/Cr metabolites ratio in only one location - the right frontal parafalcine cortex. There was no statistically significant difference in NAA/Cho ratio between men and women.
CONCLUSION
Our study suggests that right frontal parafalcine cortex is a sexually dysmorphic area and supports the value of multivoxel MRS as a method able to define spatial biochemical heterogeneity of the cerebral tissue.
目的
通过多体素磁共振波谱（MRS）确定健康男性和女性之间是否存在性别神经代谢差异。
材料与方法
我们使用1.5T扫描仪对50名健康志愿者（27名女性和23名男性）进行了多体素磁共振成像和波谱分析。从12个不同体素获取波谱，覆盖额叶、中央旁和顶叶的白质和灰质。分析了三个主要信号：NAA、tCr和Cho，并以Cho/tCr、NAA/tCr、NAA/Cho的比率表示。
结果
仅在一个位置——右侧额叶镰旁皮质，Cho/Cr和NAA/Cr代谢物比率存在统计学上的显著性别差异。男性和女性之间的NAA/Cho比率没有统计学上的显著差异。
结论
我们的研究表明，右侧额叶镰旁皮质是一个性二态区，并支持多体素MRS作为一种能够定义脑组织空间生化异质性的方法的价值。
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