Di Bella Giuseppe
Di Bella Foundation (Fondazione Di Bella), Bologna, Italy.
Neuro Endocrinol Lett. 2011;32(6):751-62.
To increase the efficacy and reduce the toxicity of cancer therapy.
The DBM with MLT (melatonin), Retinoids, vitamins E, D3, and C has a differentiating, cytostatic, antiangiogenic, immunomodulating, factorially synergic effect, at the same time reinforcing those functions that Physiology considers essential for life. With Somatostatin and/or its analogues, the DBM has an antiproliferative effect, negatively regulating the most powerful mitogenic molecule (GH), receptorially co-expressed and interactive with Prolactin, inhibited by Cabergoline and/or Bromocriptin. The negative regulation of GH extends directly to the GH-dependent growth factors. In breast cancer, the DBM entails the use of estrogen inhibitors and minimal apoptotic, non-cytotoxic and non-mutagenic doses of Cyclophosphamide or Oncocarbide, the tolerability of which is enhanced by MLT and the vitamins in the DBM.
Complete and stable cure of 4 cases, and rapid regression of the tumour in another 5 cases with just the DBM (first-line therapy), without surgical intervention. No disease recurrence with the use of the DBM as adjuvant therapy. Five-year survival of 50%, of stage IV cases, considerably higher than the data reported in the literature. A more or less generalised improvement in the quality of life, without any significant and/or prolonged toxicity.
The acknowledgement of the still underestimated scientific evidence, such as the multiple antitumoral mechanisms of action of MLT, the negative regulation of the interactive mitogens GH-GF (GH-dependent growth factors), Prolactin and estrogens, together with the differentiating and homeostatic action of retinoids and Vitamins E, D3, and C and MLT, made it possible to achieve these results. An essential aspect of the mechanism of action on the clinical response is the factorial synergy of the DBM components.
提高癌症治疗的疗效并降低其毒性。
含有褪黑素（MLT）、维甲酸、维生素E、D3和C的双膦酸盐（DBM）具有分化、细胞生长抑制、抗血管生成、免疫调节和协同效应，同时增强生理上认为对生命至关重要的那些功能。与生长抑素和/或其类似物一起，DBM具有抗增殖作用，对最强有力的促有丝分裂分子（生长激素，GH）进行负调节，GH与催乳素受体共表达且相互作用，并被卡麦角林和/或溴隐亭抑制。GH的负调节直接扩展到依赖GH的生长因子。在乳腺癌中，DBM需要使用雌激素抑制剂以及最小凋亡、无细胞毒性和无诱变作用剂量的环磷酰胺或癌可安，DBM中的MLT和维生素可增强其耐受性。
仅使用DBM（一线治疗），4例患者实现完全稳定治愈，另外5例患者肿瘤迅速消退，无需手术干预。使用DBM作为辅助治疗无疾病复发。IV期病例的五年生存率为50%，远高于文献报道的数据。生活质量有或多或少的普遍改善，无任何显著和/或长期毒性。
认识到仍被低估的科学证据，如MLT的多种抗肿瘤作用机制、相互作用的促有丝分裂原GH - GF（依赖GH的生长因子）、催乳素和雌激素的负调节，以及维甲酸和维生素E、D3、C和MLT的分化和稳态作用，使得能够取得这些结果。DBM各成分的协同作用是对临床反应作用机制的一个重要方面。
