Di Bella Foundation, Via Guglielmo Marconi 51, Bologna 40122, Italy.
Int J Mol Sci. 2013 Jan 24;14(2):2410-30. doi: 10.3390/ijms14022410.
Melatonin (N-acetyl-5-methoxytryptamine, MLT), the main hormone produced by the pineal gland, not only regulates circadian rhythm, but also has antioxidant, anti-ageing and immunomodulatory properties. MLT plays an important role in blood composition, medullary dynamics, platelet genesis, vessel endothelia, and in platelet aggregation, leukocyte formula regulation and hemoglobin synthesis. Its significant atoxic, apoptotic, oncostatic, angiogenetic, differentiating and antiproliferative properties against all solid and liquid tumors have also been documented. Thanks, in fact, to its considerable functional versatility, MLT can exert both direct and indirect anticancer effects in factorial synergy with other differentiating, antiproliferative, immunomodulating and trophic molecules that form part of the anticancer treatment formulated by Luigi Di Bella (Di Bella Method, DBM: somatostatin, retinoids, ascorbic acid, vitamin D3, prolactin inhibitors, chondroitin-sulfate). The interaction between MLT and the DBM molecules counters the multiple processes that characterize the neoplastic phenotype (induction, promotion, progression and/or dissemination, tumoral mutation). All these particular characteristics suggest the use of MLT in oncological diseases.
褪黑素（N-乙酰-5-甲氧基色胺，MLT），是松果腺分泌的主要激素，不仅调节昼夜节律，还具有抗氧化、抗衰老和免疫调节特性。MLT 在血液成分、骨髓动力学、血小板生成、血管内皮和血小板聚集、白细胞公式调节和血红蛋白合成中发挥重要作用。它对所有实体瘤和液体瘤具有显著的非毒性、凋亡、抗肿瘤、血管生成、分化和抗增殖特性，也已得到证实。事实上，由于其相当大的多功能性，MLT 可以与其他分化、抗增殖、免疫调节和营养分子形成协同作用，发挥直接和间接的抗癌作用，这些分子是 Luigi Di Bella（Di Bella 方法，DBM：生长抑素、类视黄醇、抗坏血酸、维生素 D3、催乳素抑制剂、硫酸软骨素）制定的抗癌治疗方案的一部分。MLT 与 DBM 分子之间的相互作用可以对抗肿瘤表型的多种过程（诱导、促进、进展和/或传播、肿瘤突变）。所有这些特殊特征都表明 MLT 可用于治疗肿瘤疾病。
