Sekiya Ryo, Yamazaki Hiroshi, Izawa Kazumi, Kaneko Akihiro, Tsukinoki Keiichi
Department of Oral Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Tokai J Exp Clin Med. 2011 Dec 20;36(4):124-7.
Adenomatoid odontogenic tumor (AOT) is a relatively rare benign tumor, accounting for 2% to 7% of odontogenic tumors. AOT is generally found in the incisor region of the maxilla of young women. It is often misdiagnosed as a dentigerous cyst. We report a case of AOT during pregnancy. The patient was a 21-year-old Philippine woman who complained of a swelling in the right maxillary gingival; the swelling rapidly enlarged during pregnancy. We enucleated the tumor and the impacted canine, with the patient under general anesthesia. Histological examination revealed a pseudoglandular structure with odontogenic appearance. On the basis of these findings and the World health organization (WHO) classification, we diagnosed the tumor as an adenomatoid odontogenic tumor. The tumor cells were identified by an immunohistochemically positive reaction for Bcl-2 and estrogen receptor. The MIB-1 labeling index was less than 1%. There has been no sign of recurrence as of 1.5 years after the operation.
腺牙源性肿瘤（AOT）是一种相对罕见的良性肿瘤，占牙源性肿瘤的2%至7%。AOT通常见于年轻女性上颌切牙区，常被误诊为含牙囊肿。我们报告一例妊娠期腺牙源性肿瘤病例。患者为一名21岁的菲律宾女性，主诉右上颌牙龈肿胀；孕期肿胀迅速增大。在全身麻醉下，我们摘除了肿瘤及阻生尖牙。组织学检查显示为具有牙源性外观的假腺管结构。基于这些发现及世界卫生组织（WHO）分类，我们将该肿瘤诊断为腺牙源性肿瘤。肿瘤细胞通过Bcl-2和雌激素受体免疫组化阳性反应得以鉴定。MIB-1标记指数小于1%。截至术后1.5年，尚无复发迹象。
