Sethi Sneha, Kumar Manish, Aggarwal Pratul, Indra Kumar H S, Sugandhi Chetan D, Singh Silvie
Department of Oral and Maxillofacial Pathology, Sudha Rustagi College of Dental Sciences and Research, Faridabad, Haryana, India.
Department of Oral and Maxillofacial Pathology, Tatyasaheb Kore Dental College and Research Centre, Kohlapur, Maharashtra, India.
Dent Res J (Isfahan). 2016 Sep;13(5):462-471. doi: 10.4103/1735-3327.192312.
Adenomatoid odontogenic tumor (AOT) is an uncommon benign odontogenic lesion, with debatable histogenesis and variable histopathology. A systematic and diverse insight into the evolution, clinical presentation, histology, and immunohistochemical findings of this lesion is reviewed and presented. We reviewed the data published from 2000 to 2014 of approximately 255 cases that revealed a significant change in the incidence of predominant site involved, in contrast to the findings published by Reichart. We have also included the chronological order of events leading to the coining of the term AOT, which shows the curiosity that has been dedicated to understanding the lesion. Immunohistochemistry is considered to be a hallmark in pathology for learning the molecular pathogenesis and giving a correct final diagnosis. Several markers have been used to investigate and understand this lesion, and a compilation of the findings has been tabulated.
腺样牙源性肿瘤（AOT）是一种罕见的良性牙源性病变，其组织发生存在争议，组织病理学表现多样。本文对该病变的演变、临床表现、组织学及免疫组化结果进行了系统且全面的综述。我们回顾了2000年至2014年发表的约255例数据，这些数据显示，与Reichart发表的结果相比，主要受累部位的发生率有显著变化。我们还纳入了导致“腺样牙源性肿瘤”这一术语产生的事件年表，这显示了人们为理解该病变所付出的努力。免疫组化被认为是病理学中了解分子发病机制并做出正确最终诊断的关键。已有多种标志物用于研究和理解该病变，现将研究结果汇总列表。
