Department of Obstetrics and Gynaecology, Namsos Hospital, Namsos, Norway.
BJOG. 2012 Feb;119(3):266-75. doi: 10.1111/j.1471-0528.2011.03206.x. Epub 2011 Dec 13.
To test the hypothesis that endocrine and metabolic factors predispose to preterm birth.
A cross-sectional, case-control study.
Namsos Hospital district (Namsos, Norway).
Women from the Namsos Hospital district with previous preterm births (n = 114) were compared with matched controls with term births (n = 127).
A clinical examination including transvaginal ultrasound was performed. Fasting blood samples were collected and an oral glucose tolerance test was performed.
The prevalence of polycystic ovary syndrome (PCOS) diagnosis (Rotterdam criteria) and serum levels of androgens, glucose and insulin.
Twenty-nine of 114 women (25.4%) met the PCOS criteria among women with preterm birth, compared with 18 of 127 (14.2%) among controls (P = 0.03). Eight (7.1%) women with preterm birth were diagnosed with diabetes compared with none in the control group (P < 0.01). Hirsutism was present in 34 (29.8%) women with preterm birth versus 12 (9.4%) in the control group (P < 0.01).
The prevalences of PCOS, diabetes and hirsutism are increased among women with a history of preterm birth. This indicates that endocrine and/or metabolic factors may be involved in the pathogenesis of preterm birth. Women experiencing preterm delivery may have an increased risk of developing diabetes and PCOS later in life.
验证内分泌和代谢因素易导致早产的假说。
一项横断面、病例对照研究。
纳姆斯（Namsos）医院区（挪威纳姆斯）。
纳姆斯医院区有早产史的妇女（n=114）与足月产的匹配对照（n=127）进行比较。
进行了包括经阴道超声的临床检查。采集空腹血样并进行口服葡萄糖耐量试验。
多囊卵巢综合征（PCOS）诊断（鹿特丹标准）的患病率以及雄激素、葡萄糖和胰岛素的血清水平。
早产组 114 名妇女中有 29 名（25.4%）符合 PCOS 标准，而对照组 127 名妇女中有 18 名（14.2%）符合标准（P=0.03）。早产组有 8 名（7.1%）妇女被诊断为糖尿病，而对照组中无 1 例（P<0.01）。早产组有 34 名（29.8%）妇女有多毛症，而对照组中仅有 12 名（9.4%）（P<0.01）。
有早产史的妇女中 PCOS、糖尿病和多毛症的患病率增加。这表明内分泌和/或代谢因素可能参与了早产的发病机制。经历早产的妇女以后可能会有更高的糖尿病和 PCOS 发病风险。
