Christiansen Sverre C, Eilertsen Tina B, Vanky Eszter, Carlsen Sven M
Department of Endocrinology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
PLoS One. 2016 Jan 22;11(1):e0146739. doi: 10.1371/journal.pone.0146739. eCollection 2016.
Increased Anti-Mullerian Hormone in polycystic ovary syndrome, may be due to overactive follicles rather than reflect antral follicle count.
Does Anti-Mullerian Hormone reflect antral follicle count similarly in women with or without polycystic ovary syndrome or polycystic ovarian morphology?
Cross-sectional, case-control.
Women who delivered preterm in 1999-2006. For each index woman, a woman with a term delivery was identified.
Participation rate was 69%. Between 2006-2008, 262 women were included, and diagnosed to have polycystic ovary syndrome, polycystic ovarian morphology or to be normal controls.
INTERVENTION(S): Blood tests, a clinical examination and vaginal ultrasound.
MAIN OUTCOME MEASURE(S): Anti-Mullerian Hormone/antral follicle count-ratio, SHBG, androstenedione and insulin, to test potential influence on the Anti-Mullerian Hormone/antral follicle count -ratio.
Mean Anti-Mullerian Hormone/antral follicle count ratio in women with polycystic ovary syndrome or polycystic ovarian morphology was similar to that of the controls (polycystic ovary syndrome: 1,2 p = 0,10 polycystic ovarian morphology: 1,2, p = 0,27 Controls 1,3). Anti-Mullerian Hormone showed a positive linear correlation to antral follicle count in all groups. Multivariate analysis did not change the results.
We confirmed the positive correlation between AMH and follicle count. Anti-Mullerian Hormone seems to be a reliable predictor of antral follicle count, independent of polycystic ovary syndrome diagnosis or ovarian morphology.
多囊卵巢综合征患者抗苗勒管激素水平升高，可能是由于卵泡过度活跃，而非反映窦卵泡计数。
在患有或未患有多囊卵巢综合征或多囊卵巢形态的女性中，抗苗勒管激素反映窦卵泡计数的情况是否相似？
横断面病例对照研究。
1999年至2006年早产的女性。为每位索引女性确定一名足月分娩的女性。
参与率为69%。2006年至2008年期间，纳入了262名女性，诊断为患有多囊卵巢综合征、多囊卵巢形态或作为正常对照。
血液检查、临床检查和阴道超声检查。
抗苗勒管激素/窦卵泡计数比值、性激素结合球蛋白、雄烯二酮和胰岛素，以测试对抗苗勒管激素/窦卵泡计数比值的潜在影响。
多囊卵巢综合征或多囊卵巢形态女性的平均抗苗勒管激素/窦卵泡计数比值与对照组相似（多囊卵巢综合征：1.2，p = 0.10；多囊卵巢形态：1.2，p = 0.27；对照组：1.3）。抗苗勒管激素在所有组中均与窦卵泡计数呈正线性相关。多变量分析未改变结果。
我们证实了抗苗勒管激素与卵泡计数之间的正相关。抗苗勒管激素似乎是窦卵泡计数的可靠预测指标，与多囊卵巢综合征诊断或卵巢形态无关。
