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离散失效时间数据的半参数平滑法

Semiparametric smoothing of discrete failure time data.

作者信息

Patil Prakash N, Bagkavos Dimitrios

机构信息

School of Mathematics and Statistics, The University of Birmingham, Birmingham, B15 2TT, UK.

出版信息

Biom J. 2012 Jan;54(1):5-19. doi: 10.1002/bimj.201100058. Epub 2011 Dec 14.

Abstract

An estimator of the hazard rate function from discrete failure time data is obtained by semiparametric smoothing of the (nonsmooth) maximum likelihood estimator, which is achieved by repeated multiplication of a Markov chain transition-type matrix. This matrix is constructed so as to have a given standard discrete parametric hazard rate model, termed the vehicle model, as its stationary hazard rate. As with the discrete density estimation case, the proposed estimator gives improved performance when the vehicle model is a good one and otherwise provides a nonparametric method comparable to the only purely nonparametric smoother discussed in the literature. The proposed semiparametric smoothing approach is then extended to hazard models with covariates and is illustrated by applications to simulated and real data sets.

摘要

通过对(非光滑的)极大似然估计进行半参数平滑,可得到基于离散失效时间数据的风险率函数估计量,这是通过马尔可夫链转移型矩阵的重复乘法来实现的。构建该矩阵是为了使其具有一个给定的标准离散参数风险率模型(称为载体模型)作为其平稳风险率。与离散密度估计情况一样,当载体模型合适时,所提出的估计量性能会得到改善,否则提供一种与文献中讨论的唯一纯非参数平滑器相当的非参数方法。然后,将所提出的半参数平滑方法扩展到具有协变量的风险模型,并通过应用于模拟数据集和真实数据集进行说明。

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