Human Nutrition Unit, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
Am J Clin Nutr. 2012 Jan;95(1):249-55. doi: 10.3945/ajcn.111.016642. Epub 2011 Dec 14.
Osteocalcin has been related to insulin secretion in experimental models. Few prospective studies have evaluated the association between circulating osteocalcin concentrations and insulin secretion and sensitivity in humans.
The objective was to examine cross-sectional and longitudinal associations between circulating forms of osteocalcin and insulin secretion and sensitivity in elderly men at high cardiovascular risk.
We examined cross-sectional and longitudinal associations between serum measurements of total osteocalcin and undercarboxylated osteocalcin (ucOC) with fasting glucose, fasting insulin, HOMA-IR, and HOMA β cell function (HOMA-BCF) in 79 elderly men. We also examined the association between 2-y changes in osteocalcin and changes in fasting glucose, insulin, HOMA-IR, and HOMA-BCF.
In an adjusted multivariable linear regression analysis, increases in serum osteocalcin were significantly associated with an increase in HOMA-BCF (β coefficient: 2.87; 95% CI: 0.23, 5.52; P = 0.033), and changes in ucOC were linked to a decrease in HOMA-IR (β coefficient: -0.31; 95% CI: -0.60, 0.03; P = 0.032). Moreover, in subjects not taking oral antidiabetic drugs, baseline osteocalcin concentrations were positively associated with higher fasting insulin concentrations and HOMA-BCF even after adjustment for BMI, physical activity, intervention group, presence of type 2 diabetes mellitus, and baseline values of each dependent variable.
Changes in serum osteocalcin and ucOC are associated with an improvement in insulin secretion and sensitivity, which suggests a possible role of bone in the development of type 2 diabetes. This trial is registered at clinicaltrials.gov as ISRCTN35739639.
骨钙素与实验模型中的胰岛素分泌有关。少数前瞻性研究评估了循环骨钙素浓度与人类胰岛素分泌和敏感性之间的关系。
本研究旨在研究高心血管风险的老年男性中循环骨钙素形式与胰岛素分泌和敏感性的横断面和纵向关系。
我们研究了 79 名老年男性血清总骨钙素和非羧化骨钙素（ucOC）与空腹血糖、空腹胰岛素、HOMA-IR 和 HOMA-β 细胞功能（HOMA-BCF）之间的横断面和纵向关系。我们还研究了骨钙素 2 年变化与空腹血糖、胰岛素、HOMA-IR 和 HOMA-BCF 变化之间的关系。
在调整后的多元线性回归分析中，血清骨钙素的增加与 HOMA-BCF 的增加显著相关（β系数：2.87；95%CI：0.23，5.52；P=0.033），ucOC 的变化与 HOMA-IR 的降低相关（β系数：-0.31；95%CI：-0.60，0.03；P=0.032）。此外，在未服用口服降糖药的受试者中，基线骨钙素浓度与空腹胰岛素浓度和 HOMA-BCF 升高呈正相关，即使在调整 BMI、体力活动、干预组、2 型糖尿病的存在和每个因变量的基线值后也是如此。
血清骨钙素和 ucOC 的变化与胰岛素分泌和敏感性的改善相关，这表明骨骼在 2 型糖尿病的发生发展中可能起作用。该试验在 clinicaltrials.gov 上注册为 ISRCTN35739639。
