IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
J Invest Dermatol. 2012 Mar;132(3 Pt 2):976-84. doi: 10.1038/jid.2011.394. Epub 2011 Dec 15.
The health consequences of sun exposure have concerned mankind for more than 100 years. Recent molecular studies in photodermatology have greatly advanced our understanding of this important topic. We will illustrate this progress by focusing on the following selected topics: (i) the nature of the DNA damage-independent part of the UVB response of human skin and the role of the arylhydrocarbon receptor in cutaneous biology, (ii) the contribution of wavelengths beyond the UV spectrum to solar radiation-induced skin damage, (iii) the emerging evidence that subcutaneous fat is a target tissue for sunlight, and (iv) the most recent insight into the mode of action of phototherapy.
日光照射对健康的影响已经引起人类关注超过 100 年。近年来，光皮肤病学领域的分子研究极大地推动了我们对这一重要课题的理解。我们将通过以下选定的主题来说明这一进展：（i）人类皮肤中 UVB 反应中 DNA 损伤非依赖性部分的本质以及芳香烃受体在皮肤生物学中的作用，（ii）超出 UV 光谱范围的波长对太阳辐射引起的皮肤损伤的贡献，（iii）越来越多的证据表明皮下脂肪是阳光的靶组织，以及（iv）光疗作用模式的最新见解。
