Benedusi Mascia, Kerob Delphine, Guiotto Anna, Cervellati Franco, Ferrara Francesca, Pambianchi Erika
Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
L'Oreal Dermatological Beauty, Levallois, France.
Clin Cosmet Investig Dermatol. 2023 Jul 8;16:1769-1776. doi: 10.2147/CCID.S414011. eCollection 2023.
Exposure of the skin to ultraviolet radiation (UV) or ozone (O) results in stressed skin, leading to the alteration of the skin physical barrier and defence functions. In this work, the preventive benefit of a dermocosmetic, M89PF, containing Vichy mineralising water, probiotic fractions, antioxidant vitamins and hyaluronic acid, in the alteration of skin physical barrier and skin defence functions after exposure to O and UV, alone or combined, was assessed.
Untreated and treated (M89PF) skin explants were exposed to O, to UV rays or to O+UV. Immunofluorescence was performed for skin barrier, oxidative stress, and inflammatory markers after one and four days of exposure to the pollutants.
M89PF significantly (p≤0.05) prevented the decrease of the expression level of different skin barrier markers, and significantly (p≤0.05) prevented the induction of OxInflammatory markers and inflammasome components by UV, O or both combined.
M89PF prevents skin barrier damage, as well as oxidative stress and inflammatory markers induced by exposome factors, such as UV, O or both combined.
皮肤暴露于紫外线（UV）或臭氧（O）会导致皮肤应激，进而引起皮肤物理屏障和防御功能的改变。在本研究中，评估了一种含有薇姿矿泉活肤水、益生菌成分、抗氧化维生素和透明质酸的皮肤美容产品M89PF，对皮肤在单独或联合暴露于O和UV后，其物理屏障和皮肤防御功能改变的预防作用。
将未处理和经M89PF处理的皮肤外植体暴露于O、紫外线或O+UV。在暴露于污染物1天和4天后，对皮肤屏障、氧化应激和炎症标志物进行免疫荧光检测。
M89PF显著（p≤0.05）预防了不同皮肤屏障标志物表达水平的降低，并且显著（p≤0.05）预防了紫外线、O或两者联合诱导的氧化炎症标志物和炎性小体成分的产生。
M89PF可预防皮肤屏障损伤，以及由暴露因素如紫外线、O或两者联合诱导的氧化应激和炎症标志物。
