Skulachev Vladimir P
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119991, Russia.
Aging (Albany NY). 2011 Nov;3(11):1045-50. doi: 10.18632/aging.100410.
Effects of the mitochondria-targeted antioxidant SkQ1 and food restriction are compared. In both cases there is a remarkable increase in the median lifespan of organisms belonging to many different taxonomic ranks. Essentially, both SkQ1 treatment and restriction in food intake retard development of numerous adverse traits of senescence. This relationship could be predicted assuming that SkQ1 and food restriction inhibit the execution of an aging program. It is hypothesized that food restriction is perceived by organisms as a signal of starvation, which can be catastrophic for the population. Under these conditions, the organism switches off an aging program that is favorable for evolvability of the species but counterproductive for the individual. Unfortunately, food restriction is accompanied by some other effects, e.g., constant anxiety and attempts to scan as large a space as possible looking for food. Such side effects seem to be absent in the case of inhibition of the aging program by SkQ1.
比较了线粒体靶向抗氧化剂SkQ1和食物限制的效果。在这两种情况下，属于许多不同分类等级的生物的中位寿命都有显著增加。从本质上讲，SkQ1处理和食物摄入量限制都能延缓衰老的许多不良特征的发展。假设SkQ1和食物限制抑制衰老程序的执行，这种关系是可以预测的。据推测，食物限制被生物体视为饥饿信号，这对种群可能是灾难性的。在这种情况下，生物体关闭了一个有利于物种进化但对个体适得其反的衰老程序。不幸的是，食物限制还伴随着一些其他影响，例如持续的焦虑以及试图尽可能大范围地寻找食物。而在SkQ1抑制衰老程序的情况下，似乎不存在这些副作用。
