Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Bioinformatics. 2012 Feb 1;28(3):441-3. doi: 10.1093/bioinformatics/btr684. Epub 2011 Dec 14.
Many protein-protein interactions are more complex than can be accounted for by 1:1 binding models. However, biochemists have few tools available to help them recognize and predict the behaviors of these more complicated systems, making it difficult to design experiments that distinguish between possible binding models. MTBindingSim provides researchers with an environment in which they can rapidly compare different models of binding for a given scenario. It is written specifically with microtubule polymers in mind, but many of its models apply equally well to any polymer or any protein-protein interaction. MTBindingSim can thus both help in training intuition about binding models and with experimental design.
MTBindingSim is implemented in MATLAB and runs either within MATLAB (on Windows, Mac or Linux) or as a binary without MATLAB (on Windows or Mac). The source code (licensed under the GNU General Public License) and binaries are freely available at http://mtbindingsim.googlecode.com.
许多蛋白质-蛋白质相互作用比 1:1 结合模型更为复杂。然而,生物化学家可用的工具很少,无法帮助他们识别和预测这些更为复杂的系统的行为,从而难以设计出能够区分可能的结合模型的实验。MTBindingSim 为研究人员提供了一个环境,使他们能够快速比较给定情况下不同的结合模型。它是专门针对微管聚合物而编写的,但它的许多模型同样适用于任何聚合物或任何蛋白质-蛋白质相互作用。因此,MTBindingSim 既可以帮助培养对结合模型的直觉,也可以帮助进行实验设计。
MTBindingSim 是用 MATLAB 编写的,可以在 MATLAB 内部(在 Windows、Mac 或 Linux 上)运行,也可以作为没有 MATLAB 的二进制文件(在 Windows 或 Mac 上)运行。源代码(根据 GNU 通用公共许可证获得许可)和二进制文件可在 http://mtbindingsim.googlecode.com 上免费获得。