相似文献
1
Novel bioactive metabolites of dipyrone (metamizol).
Bioorg Med Chem. 2012 Jan 1;20(1):101-7. doi: 10.1016/j.bmc.2011.11.028. Epub 2011 Nov 25.
2
Effects of metabolites of the analgesic agent dipyrone (metamizol) on rostral ventromedial medulla cell activity in mice.
Eur J Pharmacol. 2015 Feb 5;748:115-22. doi: 10.1016/j.ejphar.2014.12.022. Epub 2014 Dec 31.
3
The analgesic effect of dipyrone in peripheral tissue involves two different mechanisms: neuronal K(ATP) channel opening and CB(1) receptor activation.
Eur J Pharmacol. 2014 Oct 15;741:124-31. doi: 10.1016/j.ejphar.2014.07.019. Epub 2014 Jul 21.
4
Evaluation of the endogenous cannabinoid system in mediating the behavioral effects of dipyrone (metamizol) in mice.
Behav Pharmacol. 2012 Oct;23(7):722-6. doi: 10.1097/FBP.0b013e3283584794.
5
Dipyrone is locally hydrolyzed to 4-methylaminoantipyrine and its antihyperalgesic effect depends on CB and kappa-opioid receptors activation.
Eur J Pharmacol. 2020 May 5;874:173005. doi: 10.1016/j.ejphar.2020.173005. Epub 2020 Feb 11.
6
Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic.
FASEB J. 2007 Aug;21(10):2343-51. doi: 10.1096/fj.06-8061com. Epub 2007 Apr 13.
7
Inhibition of cyclooxygenases by dipyrone.
Br J Pharmacol. 2007 Jun;151(4):494-503. doi: 10.1038/sj.bjp.0707239. Epub 2007 Apr 16.
8
Regulation of cyclooxygenase activity by metamizol.
Eur J Pharmacol. 1999 Aug 13;378(3):339-47. doi: 10.1016/s0014-2999(99)00477-x.
9
Quantification of 4-methylaminoantipyrine, the active metabolite of dipyrone, in human plasma.
Bioanalysis. 2009 May;1(2):293-8. doi: 10.4155/bio.09.26.
10
Monitoring of four dipyrone metabolites in communal wastewater by solid phase extraction liquid chromatography electrospray ionization quadrupole time-of-flight mass spectrometry.
J Pharm Biomed Anal. 2014 Mar;90:58-63. doi: 10.1016/j.jpba.2013.11.019. Epub 2013 Nov 24.
引用本文的文献
1
Metamizole does not affect fracture healing in a murine ischemia model.
Front Physiol. 2025 Jul 9;16:1630268. doi: 10.3389/fphys.2025.1630268. eCollection 2025.
2
Metamizole limits proliferation in chronic myeloid leukemia cells and triggers apoptosis via the bax/bcl-2/caspase-3 cascade.
Med Oncol. 2025 Jun 27;42(8):288. doi: 10.1007/s12032-025-02842-x.
3
Pharmacological Pain Treatment in Older Persons.
Drugs Aging. 2024 Dec;41(12):959-976. doi: 10.1007/s40266-024-01151-8. Epub 2024 Oct 27.
4
Effects of major analgesics on male fertility: A systematic literature review.
JBRA Assist Reprod. 2024 Jun 1;28(2):331-340. doi: 10.5935/1518-0557.20240020.
5
Opioid versus non-opioid postoperative pain management in otolaryngology.
BMC Anesthesiol. 2023 Aug 25;23(1):291. doi: 10.1186/s12871-023-02213-x.
6
2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties.
Pharmaceuticals (Basel). 2022 Dec 6;15(12):1519. doi: 10.3390/ph15121519.
7
Design, synthesis and in vivo evaluation of 1,4-dioxo-2-butenyl aryl amine derivatives as a promising anti-inflammatory drug prototype.
Bioorg Chem. 2022 Jul;124:105754. doi: 10.1016/j.bioorg.2022.105754. Epub 2022 Mar 26.
8
Pharmacokinetics of metamizole (dipyrone) as an add-on in calves undergoing umbilical surgery.
PLoS One. 2022 Mar 15;17(3):e0265305. doi: 10.1371/journal.pone.0265305. eCollection 2022.
9
Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study.
Front Pharmacol. 2021 Sep 7;12:620635. doi: 10.3389/fphar.2021.620635. eCollection 2021.
10
Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain.
Pharmacol Rep. 2020 Oct;72(5):1310-1322. doi: 10.1007/s43440-020-00137-8. Epub 2020 Jul 20.
本文引用的文献
1
TRPV1 in brain is involved in acetaminophen-induced antinociception.
PLoS One. 2010 Sep 17;5(9):e12748. doi: 10.1371/journal.pone.0012748.
2
Dopamides, vanillylamides, ethanolamides, and arachidonic acid amides of anti-inflammatory and analgesic drug substances as TRPV1 ligands.
ChemMedChem. 2008 Dec;3(12):1956-64. doi: 10.1002/cmdc.200800271.
3
Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice.
Eur J Pain. 2009 Aug;13(7):691-703. doi: 10.1016/j.ejpain.2008.09.001. Epub 2008 Oct 19.
4
Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain.
Br J Pharmacol. 2008 Feb;153(4):760-8. doi: 10.1038/sj.bjp.0707630. Epub 2007 Dec 24.
5
Inhibition of cyclooxygenases by dipyrone.
Br J Pharmacol. 2007 Jun;151(4):494-503. doi: 10.1038/sj.bjp.0707239. Epub 2007 Apr 16.
6
Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic.
FASEB J. 2007 Aug;21(10):2343-51. doi: 10.1096/fj.06-8061com. Epub 2007 Apr 13.
7
Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors.
Br J Pharmacol. 2007 Mar;150(6):766-81. doi: 10.1038/sj.bjp.0707145. Epub 2007 Feb 5.
8
The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors.
Eur J Pharmacol. 2006 Feb 15;531(1-3):280-1. doi: 10.1016/j.ejphar.2005.12.015. Epub 2006 Jan 24.
9
Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system.
J Biol Chem. 2005 Sep 9;280(36):31405-12. doi: 10.1074/jbc.M501489200. Epub 2005 Jun 29.
10
Agranulocytosis associated with dipyrone (metamizol).
Eur J Clin Pharmacol. 2005 Jan;60(11):821-9. doi: 10.1007/s00228-004-0836-y. Epub 2004 Dec 3.
Zotero 插件