Kwiatkowska Wiesława, Knysz Brygida, Drelichowska-Durawa Justyna, Czarnecki Marcin, Gąsiorowski Jacek, Biłyk Ewa, Karczewski Maciej, Witkiewicz Wojciech
Department of Angiology, Regional Specialist Hospital in Wroclaw, Research and Development Center, Poland.
Postepy Hig Med Dosw (Online). 2011 Nov 25;65:770-83. doi: 10.5604/17322693.967075.
HIV infected patients, especially those treated with antiretroviral (ARV) drugs, show an increased risk and incidence of cardiovascular disease.
The aim of this study was to evaluate the progression of subclinical atherosclerosis in the carotid arteries, expressed as the value of carotid intima-media thickness (cIMT) and the amount of atherosclerotic plaques, and to analyze the correlation between cIMT and risk factors for cardiovascular diseases in a cohort of HIV infected patients.
The analysis included 72 HIV infected patients, mean age 39.4 years, and 27 healthy HIV negative individuals, matched for age and sex. The data collected included evaluation of the infection, ARV treatment, past cardiovascular events, assessment of traditional and nontraditional risk factors for cardiovascular diseases, cIMT measurements and amount of atherosclerotic plaques in the carotid arteries.
HIV infected patients show more advanced subclinical atherosclerosis in the carotid arteries (cIMT and plaques incidence). The cardiovascular risk profile of the HIV infected patients is significantly different from HIV negative people. Among the HIV positive group lower body mass index (BMI) and higher waist/hip ratio (WHR) are observed. The concentration of all cholesterol fractions is lower, whereas the concentration of triglycerides is higher. Cigarette smoking is more common among HIV-infected individuals. A strong statistical correlation between cIMT and age, hypertension, non-high-density lipoprotein (non-HDL) cholesterol and ARV time were found. Total and LDL cholesterol, and lifetime smoking exposure also affect the cIMT. The relationship between cIMT and current HIV RNA may indicate the impact of the current infection status on the cIMT dynamics in this subpopulation.
HIV感染患者，尤其是接受抗逆转录病毒（ARV）药物治疗的患者，心血管疾病的风险和发病率增加。
本研究的目的是评估颈动脉亚临床动脉粥样硬化的进展，以颈动脉内膜中层厚度（cIMT）值和动脉粥样硬化斑块数量表示，并分析一组HIV感染患者中cIMT与心血管疾病危险因素之间的相关性。
分析包括72名HIV感染患者，平均年龄39.4岁，以及27名年龄和性别匹配的健康HIV阴性个体。收集的数据包括感染评估、ARV治疗、既往心血管事件、心血管疾病传统和非传统危险因素评估、cIMT测量以及颈动脉粥样硬化斑块数量。
HIV感染患者在颈动脉中表现出更严重的亚临床动脉粥样硬化（cIMT和斑块发生率）。HIV感染患者的心血管风险特征与HIV阴性者显著不同。在HIV阳性组中，观察到较低的体重指数（BMI）和较高的腰臀比（WHR）。所有胆固醇组分的浓度较低，而甘油三酯浓度较高。吸烟在HIV感染者中更为常见。发现cIMT与年龄、高血压、非高密度脂蛋白（non-HDL）胆固醇和ARV治疗时间之间存在很强的统计学相关性。总胆固醇和低密度脂蛋白胆固醇以及终生吸烟暴露也会影响cIMT。cIMT与当前HIV RNA之间的关系可能表明当前感染状态对该亚群中cIMT动态的影响。
