使用吡咯烷二酮（pybox）或吡咯并咪唑（pybim）配体的对映选择性锌催化酮的硅氢化反应。
Enantioselective zinc-catalyzed hydrosilylation of ketones using pybox or pybim ligands.
机构信息
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany.
出版信息
Chem Asian J. 2012 Feb 6;7(2):314-20. doi: 10.1002/asia.201100561. Epub 2011 Dec 15.
PMID:22174103
Abstract
The combination of ZnEt(2) and chiral pyridinebisoxazoline (pybox) or pyridinebisimidazoline (pybim) ligands catalyzed the asymmetric hydrosilylation of aryl, alkyl, cyclic, heterocyclic, and aliphatic ketones. Under mild conditions, high yields and good enantioselectivities were achieved. ESI measurements allowed for the characterization of the active catalyst.
摘要
ZnEt(2)与手性吡啶双恶唑啉（pybox）或吡啶双咪唑啉（pybim）配体的组合催化了芳基、烷基、环状、杂环和脂肪族酮的不对称氢硅烷化反应。在温和条件下，获得了高产率和良好的对映选择性。ESI 测量允许对活性催化剂进行表征。
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