College of Material, Chemistry and Chemical Engineering and Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, China.
Org Biomol Chem. 2011 Aug 21;9(16):5652-4. doi: 10.1039/c1ob05494e. Epub 2011 Jun 27.
In the presence of PhSiH(3) as the hydride donor, catalytic amounts of non-racemic dipyridylphosphine and an easy-to-handle cobalt salt Co(OAc)(2)·4H(2)O formed in situ an effective catalyst system for the asymmetric reduction of a diverse range of aryl alkyl ketones with moderate-to-excellent enantioselectivities (up to 96% ee). This approach tolerated the handling of both catalyst and reactants under air without special precautions.
在 PhSiH(3) 作为供氢体的存在下，催化量的非外消旋二吡啶基膦和易于处理的钴盐 Co(OAc)(2)·4H(2)O 原位形成了一种有效的不对称还原各种芳基烷基酮的催化剂体系，具有中等至优异的对映选择性（高达 96%ee）。这种方法在无需特殊预防措施的情况下，可以在空气下处理催化剂和反应物。
