同时患有幼年特发性关节炎和 1 型糖尿病——一项芬兰全国性研究。
Simultaneous juvenile idiopathic arthritis and diabetes mellitus type 1 -- a Finnish nationwide study.
机构信息
Department of Pediatrics, Päijät-Häme District Central Hospital, Lahti, Finland.
出版信息
J Rheumatol. 2012 Feb;39(2):377-81. doi: 10.3899/jrheum.110654. Epub 2011 Dec 15.
OBJECTIVE
To describe the occurrence and main clinical and laboratory findings of patients having both juvenile idiopathic arthritis (JIA) and diabetes mellitus type 1 (DM-1) in a period of 30 years.
METHODS
Eighty-two patients having simultaneous JIA and DM-1 were identified in the reimbursement registers of the Finnish National Institute of Insurance during the period 1976-2005. Data on their clinical histories were collected from patient files.
RESULTS
Occurrence of simultaneous JIA and DM-1 increased 4.5-fold between the first (1976-85) and the last (1996-2005) decade. Prevalence of uveitis was 7%, of rheumatoid factor seropositivity 15%; 22% of patients had a third autoimmune disease [autoimmune disease (AID)], and 16% had serious psychiatric problems.
CONCLUSION
The occurrence of patients with the 2 diseases, JIA and DM-1, increased over 3 decades. The prevalence of uveitis was low, the number of seropositive patients was high, and further cases of AID were frequent. Patients had multiple additional problems necessitating multiprofessional care.
目的
描述在 30 年间同时患有幼年特发性关节炎（JIA）和 1 型糖尿病（DM-1）的患者的发病情况和主要临床及实验室检查结果。
方法
在 1976-2005 年期间，我们从芬兰国家保险研究所的报销登记处确定了 82 例同时患有 JIA 和 DM-1 的患者。从患者的病历中收集了他们的临床病史数据。
结果
同时患有 JIA 和 DM-1 的患者数量在第一个十年（1976-85 年）和最后一个十年（1996-2005 年）之间增加了 4.5 倍。葡萄膜炎的患病率为 7%，类风湿因子阳性率为 15%；22%的患者患有第三种自身免疫性疾病（AID），16%的患者有严重的精神问题。
结论
在 30 多年的时间里，同时患有 JIA 和 DM-1 的患者数量增加。葡萄膜炎的患病率较低，阳性患者数量较多，而且经常出现其他自身免疫性疾病。患者存在多种其他问题，需要多专业护理。
Zotero 插件