C-美西律呼气试验重复性研究揭示重复检查时 CYP1A2 持续刺激。
C-methacetin breath test reproducibility study reveals persistent CYP1A2 stimulation on repeat examinations.
机构信息
Department of Basic Biomedical Science, School of Pharmacy, Medical University of Silesia, PL-41-205 Sosnowiec, Poland.
出版信息
World J Gastroenterol. 2011 Dec 7;17(45):4979-86. doi: 10.3748/wjg.v17.i45.4979.
AIM
To find the most reproducible quantitative parameter of a standard (13)C-methacetin breath test ((13)C-MBT).
METHODS
Twenty healthy volunteers (10 female, 10 male) underwent the (13)C-MBT after intake of 75 mg (13)C-methacetin p.o. on three occasions. Short- and medium-term reproducibility was assessed with paired examinations taken at an interval of 2 and 18 d (medians), respectively.
RESULTS
The reproducibility of the 1-h cumulative (13)C recovery (AUC(0-60)), characterized by a coefficient of variation of 10%, appeared to be considerably better than the reproducibility of the maximum momentary (13)C recovery or the time of reaching it. Remarkably, as opposed to the short gap between consecutive examinations, the capacity of the liver to handle (13)C-methacetin increased slightly but statistically significantly when a repeat dose was administered after two to three weeks. Regarding the AUC(0-60), the magnitude of this fixed bias amounted to 7.5%. Neither the time gap between the repeat examinations nor the gender of the subjects affected the (13)C-MBT reproducibility.
CONCLUSION
(13)C-MBT is most reproducibly quantified by the cumulative (13)C recovery, but the exactitude thereof may be modestly affected by persistent stimulation of CYP1A2 on repeat examinations.
目的
寻找（13）C-美他沙酮呼气试验（（13）C-MBT）中最具重现性的定量参数。
方法
20 名健康志愿者（10 名女性，10 名男性）分别在 2 天和 18 天（中位数）的间隔内进行了 3 次口服 75mg（13）C-美他沙酮后的（13）C-MBT。分别采用配对检查评估短期和中期重现性。
结果
以变异系数为 10%的 1 小时累积（13）C 回收率（AUC（0-60））的重现性似乎明显优于最大瞬时（13）C 回收率或达到该值的时间的重现性。值得注意的是，与连续检查之间的短暂间隔相反，当在两到三周后再次给予重复剂量时，肝脏处理（13）C-美他沙酮的能力略有但统计学上显著增加。关于 AUC（0-60），这种固定偏差的幅度为 7.5%。重复检查之间的时间间隔或受试者的性别均不会影响（13）C-MBT 的重现性。
结论
（13）C-MBT 最具重现性的定量参数是累积（13）C 回收率，但在重复检查时 CYP1A2 的持续刺激可能会适度影响其精确性。
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