Musialik Joanna, Jonderko Krzysztof, Kasicka-Jonderko Anna, Buschhaus Magdalena
Department of Basic Biomedical Science, School of Pharmacy in Sosnowiec, Medical University of Silesia, Katowice, Poland.
Centre for Therapeutic Discovery, Medical Research Council Technology, London, UK.
Prz Gastroenterol. 2015;10(1):1-6. doi: 10.5114/pg.2014.47501. Epub 2015 Jan 14.
In liver diagnostics, a simple, non-invasive test with high sensitivity and specificity is permanently being sought in order to assess the degree of liver damage. In addition to liver biopsy, algorithms using blood parameters or elastometry are used in clinical practice. However, these methods do not provide information about the true liver reserve, so the liver breath test seem to be a promising diagnostic tool. The basis of this test depends on the ability of particular hepatocyte enzyme systems to metabolise a tested substance labelled with a stable carbon isotope. The kinetics of (13)CO2 elimination with expiratory air then permits quantitative assessment of the functional liver reserve and the degree of organ damage. In this paper the most commonly used tests, grouped according to the main metabolic pathways, are described. The usefulness of liver breath tests in specific clinical situations, both as a diagnostic and prognostic tool, is presented.
在肝脏诊断中，人们一直在寻找一种简单、无创且具有高灵敏度和特异性的检测方法，以评估肝脏损伤程度。除了肝活检外，临床实践中还使用基于血液参数或弹性测定法的算法。然而，这些方法无法提供有关肝脏真实储备功能的信息，因此肝脏呼吸试验似乎是一种很有前景的诊断工具。该检测的基础取决于特定肝细胞酶系统代谢标记有稳定碳同位素的受试物质的能力。然后，通过呼出气体中(13)CO2的消除动力学，可以对肝脏功能储备和器官损伤程度进行定量评估。本文描述了根据主要代谢途径分类的最常用检测方法。还介绍了肝脏呼吸试验在特定临床情况下作为诊断和预后工具的实用性。
