Menard C S, Dohanich G P
Department of Psychology and Neuroscience Program, Tulane University, New Orleans, LA 70118.
Pharmacol Biochem Behav. 1990 Aug;36(4):853-8. doi: 10.1016/0091-3057(90)90089-z.
Both systemic and intracerebral administrations of the cholinergic muscarinic antagonist, scopolamine, have been shown to inhibit naturally occurring sexual behavior in intact, cycling female rats. The present study examined the facilitative effects of the acetylcholinesterase inhibitor, physostigmine (eserine), on sexual behavior in intact, cycling female rats. Cycling was determined by daily monitoring of sexual behavior and vaginal cytology. When administered during either early proestrus or proestrus, physostigmine activated lordosis 15 min and 1 hr after intraventricular infusion (10 micrograms bilaterally). However, infusion of physostigmine failed to facilitate lordosis 15 min after administration during either diestrus I, mid-diestrus, or diestrus II. The administration of this cholinergic agent did not interrupt cyclicity patterns. Because estrogen levels are highest during proestrus and cholinergic facilitation appears to be limited to this time, it is suggested that estrogen priming of central cholinergic systems is necessary for the cholinergic regulation of sexual behavior in intact, cycling female rats.
胆碱能毒蕈碱拮抗剂东莨菪碱的全身给药和脑内给药均已显示可抑制完整的、处于发情周期的雌性大鼠的自然性行为。本研究检测了乙酰胆碱酯酶抑制剂毒扁豆碱（依色林）对完整的、处于发情周期的雌性大鼠性行为的促进作用。通过每日监测性行为和阴道细胞学来确定发情周期。在动情前期早期或动情前期给药时，毒扁豆碱在脑室内注入（双侧各10微克）后15分钟和1小时激活了脊柱前凸。然而，在间情期I、间情期中段或间情期II给药后15分钟，注入毒扁豆碱未能促进脊柱前凸。这种胆碱能药物的给药并未中断发情周期模式。由于雌激素水平在动情前期最高，且胆碱能促进作用似乎仅限于这个时期，因此提示中枢胆碱能系统的雌激素启动对于完整的、处于发情周期的雌性大鼠性行为的胆碱能调节是必要的。
