Dohanich G P, Cada D A
Department of Psychology and Neuroscience Program, Tulane University, New Orleans, Louisiana 70118.
Horm Behav. 1989 Dec;23(4):503-13. doi: 10.1016/0018-506x(89)90038-x.
Androgens have been found to inhibit lordosis activated by estrogen treatment of ovariectomized female rats. In the present experiments, dihydrotestosterone propionate (200 micrograms for 3 days) inhibited the incidence of lordosis in ovariectomized females treated with estradiol benzoate (1 microgram for 3 days). This inhibition of lordosis was reversed 15 min after bilateral intraventricular infusion of physostigmine (10 micrograms/cannula), an acetylcholinesterase inhibitor, or carbachol (0.5 microgram/cannula), a cholinergic receptor agonist. This reversal of inhibition appears to be mediated by cholinergic muscarinic receptors since pretreatment with scopolamine (4 mg/kg, ip), a muscarinic receptor blocker, prevented the reversal of androgen inhibition by physostigmine. These results indicate that androgens may inhibit estrogen-activated lordosis through interference with central cholinergic muscarinic mechanisms.
已发现雄激素可抑制经雌激素处理的去卵巢雌性大鼠所激发的脊柱前凸。在本实验中，丙酸二氢睾酮（200微克，持续3天）抑制了用苯甲酸雌二醇（1微克，持续3天）处理的去卵巢雌性大鼠的脊柱前凸发生率。双侧脑室内注入乙酰胆碱酯酶抑制剂毒扁豆碱（10微克/插管）或胆碱能受体激动剂卡巴胆碱（0.5微克/插管）15分钟后，这种对脊柱前凸的抑制作用被逆转。这种抑制作用的逆转似乎是由胆碱能毒蕈碱受体介导的，因为用毒蕈碱受体阻断剂东莨菪碱（4毫克/千克，腹腔注射）预处理可防止毒扁豆碱逆转雄激素的抑制作用。这些结果表明，雄激素可能通过干扰中枢胆碱能毒蕈碱机制来抑制雌激素激活的脊柱前凸。
