Weaver D R, Clemens L G
Pharmacol Biochem Behav. 1987 Feb;26(2):393-400. doi: 10.1016/0091-3057(87)90135-3.
Drugs which alter nicotinic cholinergic transmission were administered to female rats to examine the neurochemical regulation of feminine sexual behavior. Nicotine (50, 100 or 200 micrograms/kg, IP) facilitated lordosis behavior 5 minutes after injection in estrogen-primed ovariectomized (OVX) rats. Pretreatment with the nicotinic antagonist, mecamylamine (MECA, 2.5 or 10 mg/kg) prevented this effect, while atropine pretreatment (30 mg/kg) reduced it. Mecamylamine pretreatment also reduced lordotic behavior induced by bilateral intracerebroventricular (ICV) injection of the cholinesterase inhibitor, eserine (5 micrograms/cannula). However, MECA treatment (5 or 10 micrograms/cannula, bilaterally, ICV, or 5 or 10 mg/kg, IP) did not reduce sexual receptivity in OVX rats made highly receptive with estrogen plus progesterone priming. By comparison with previously published results, MECA is apparently less effective than muscarinic antagonists in disrupting sexual receptivity in several paradigms. There appears to be a critical muscarinic link in the neural circuit for sexual receptivity, but there does not appear to be a comparable nicotinic link. In fact, the lordosis-facilitating effect of nicotine may be a pharmacological effect unrelated to the normal neurochemical regulation of sexual receptivity.
给雌性大鼠注射改变烟碱型胆碱能传递的药物，以研究雌性性行为的神经化学调节。尼古丁（50、100或200微克/千克，腹腔注射）在注射后5分钟可促进雌激素预处理的去卵巢（OVX）大鼠的脊柱前凸行为。用烟碱拮抗剂美加明（MECA，2.5或10毫克/千克）预处理可阻止这种作用，而阿托品预处理（30毫克/千克）则可减弱该作用。美加明预处理还可减弱双侧脑室内（ICV）注射胆碱酯酶抑制剂毒扁豆碱（5微克/插管）诱导的脊柱前凸行为。然而，MECA处理（5或10微克/插管，双侧，ICV，或5或10毫克/千克，腹腔注射）并未降低经雌激素加孕酮预处理而具有高接受性的OVX大鼠的性接受能力。与先前发表的结果相比，在几种实验范式中，MECA在破坏性接受能力方面显然不如毒蕈碱拮抗剂有效。在性接受能力的神经回路中似乎存在关键的毒蕈碱联系，但似乎不存在类似的烟碱联系。实际上，尼古丁促进脊柱前凸的作用可能是一种与性接受能力的正常神经化学调节无关的药理作用。
