Babcock A M, Barton C
Department of Psychology, University of South Alabama, Mobile 36688.
Pharmacol Biochem Behav. 1990 Aug;36(4):863-7. doi: 10.1016/0091-3057(90)90091-u.
Bombesin-like peptides are widely distributed in the mammalian central nervous system and participate in the regulation of a variety of autonomic functions. Central injection of bombesin produces hypothermia at normal ambient temperatures, but only if the rat has been food-deprived or made hypoglycemic with insulin. Two experiments were conducted to reevaluate the impact of bombesin microinfusion into the hypothalamic paraventricular nucleus (PVN) on core body temperature and feeding behavior. In Experiment 1, bombesin (0.05 and 0.1 microgram/1.0 microliter) produced hypothermia, but not hypophagia, in rats (n = 5) pretreated with insulin (10 U/kg; IM). Since a similar response was observed in rats with injection sites adjacent to the PVN, a smaller injection volume was evaluated in Experiment 2. Hypothermia, but not hypophagia, was observed in rats (n = 5) pretreated with insulin following bombesin (0.025 and 0.05 micrograms/0.5 microliter). Bombesin did not produce hypothermia in rats with injection sites outside of the PVN. These findings suggest that the PVN is a sensitive site for bombesin-induced hypothermia.
蛙皮素样肽广泛分布于哺乳动物中枢神经系统，并参与多种自主功能的调节。在正常环境温度下，向中枢注射蛙皮素会导致体温过低，但前提是大鼠已被禁食或用胰岛素使其血糖降低。进行了两项实验，以重新评估向下丘脑室旁核（PVN）微量注射蛙皮素对核心体温和摄食行为的影响。在实验1中，蛙皮素（0.05和0.1微克/1.0微升）在预先注射胰岛素（10 U/kg；肌肉注射）的大鼠（n = 5）中引起体温过低，但未引起摄食减少。由于在注射部位邻近PVN的大鼠中观察到类似反应，因此在实验2中评估了较小的注射体积。在预先注射胰岛素的大鼠（n = 5）中，注射蛙皮素（0.025和0.05微克/0.5微升）后观察到体温过低，但未观察到摄食减少。在注射部位位于PVN之外的大鼠中，蛙皮素未引起体温过低。这些发现表明，PVN是蛙皮素诱导体温过低的敏感部位。
