Babcock A M, Barton C, Perez L, Hearndon F
Department of Psychology, University of South Alabama, Mobile 36688.
Neuropharmacology. 1989 Apr;28(4):437-40. doi: 10.1016/0028-3908(89)90043-9.
Previous studies have shown that central injection of bombesin produces hypothermia in food-deprived, but not food satiated rats at normal ambient temperatures. The present study evaluated the effects of bombesin on core body temperature (Tb) and feeding behavior in rats pretreated with insulin. Administration of bombesin (0.25, 0.5, and 1.0 microgram) into the lateral cerebral ventricle produced hypothermia in rats injected with insulin (10 U/kg; i.m.). No significant change in core temperature was observed in control rats following bombesin. Insulin treatments significantly stimulated feeding behavior and the highest dose of bombesin significantly reduced feeding behavior. The results demonstrate bombesin-induced hypothermia under metabolic conditions similar to acute starvation. These findings are consistent with the hypothesis that bombesin-induced hypothermia in food-deprived rats is directly related to the fasting state.
先前的研究表明，在正常环境温度下，向食物匮乏而非饱腹的大鼠脑内注射蛙皮素会导致体温过低。本研究评估了蛙皮素对预先注射胰岛素的大鼠核心体温（Tb）和摄食行为的影响。向侧脑室注射蛙皮素（0.25、0.5和1.0微克）会使注射胰岛素（10 U/kg；肌肉注射）的大鼠体温过低。注射蛙皮素后，对照大鼠的核心体温未观察到显著变化。胰岛素治疗显著刺激了摄食行为，而最高剂量的蛙皮素显著降低了摄食行为。结果表明，在类似于急性饥饿的代谢条件下，蛙皮素会引起体温过低。这些发现与以下假设一致，即食物匮乏大鼠中蛙皮素诱导的体温过低与禁食状态直接相关。
