Barton C, Babcock A M
Department of Psychology, University of South Alabama, Mobile 36688.
Brain Res Bull. 1990 Nov;25(5):775-7. doi: 10.1016/0361-9230(90)90057-7.
The tetradecapeptide bombesin is a potent agent in producing hypothermia when injected centrally. Bombesin-induced hypothermia at normal ambient temperature occurs under conditions of food deprivation or insulin-induced hypoglycemia. This experiment examined the effect of refeeding on the duration of bombesin-induced hypothermia. Rats (n = 7) received microinfusions of bombesin (0.1 microgram/1.0 microliter) into the preoptic area under separate conditions of food deprivation (18 h) and insulin pretreatment (10 U/kg, IM). Core body temperature was evaluated over a period of 4 h with or without food available during testing. Hypothermia was observed under all conditions during the first 2 h. Food-deprived and insulin-pretreated rats not permitted access to food remained hypothermic until at least 4 h following bombesin. These results are discussed in terms of the possible role of glucose availability in the production and duration of bombesin-induced hypothermia.
十四肽铃蟾肽经中枢注射时是一种强效的致体温过低剂。在正常环境温度下，铃蟾肽诱导的体温过低发生在食物剥夺或胰岛素诱导的低血糖条件下。本实验研究了重新喂食对铃蟾肽诱导的体温过低持续时间的影响。大鼠（n = 7）在食物剥夺（18小时）和胰岛素预处理（10 U/kg，肌肉注射）的不同条件下，接受向视前区微量注射铃蟾肽（0.1微克/1.0微升）。在测试期间，有或没有食物供应的情况下，对核心体温进行了4小时的评估。在最初的2小时内，所有条件下均观察到体温过低。未被允许获取食物的食物剥夺和胰岛素预处理大鼠在注射铃蟾肽后至少4小时内仍处于体温过低状态。这些结果从葡萄糖可用性在铃蟾肽诱导的体温过低的产生和持续时间中可能发挥的作用方面进行了讨论。
