Veterans Administration, Tennessee Valley Healthcare System, Tennessee Valley Geriatric Research Education Clinical Center, VA National Quality Scholars Fellowship Program, Nashville, TN, USA.
Diabet Med. 2012 Sep;29(9):1126-33. doi: 10.1111/j.1464-5491.2011.03548.x.
To determine the proportion of patients who achieved blood pressure control during the 2 years following new diabetes diagnosis.
A retrospective cohort of veterans ≥ 18 years with hypertension who initiated a diabetes medication from 2000 to 2007 in the Veterans Administration Mid-South Network was assembled. Blood pressure control at diabetes treatment initiation (baseline) was compared with blood pressure control 6, 12, 18 and 24 months later. The Veterans Affairs and American Diabetes Association definitions of control, ≤ 140/90 and ≤ 130/80 mmHg, respectively, were primary and secondary outcomes.
At baseline, 59.5% of 16,182 patients had controlled blood pressure according to the Veterans Affairs guideline (31.5% using American Diabetes Association definition). Six months following initiation of diabetes treatment, 65.7% had their blood pressure controlled (P < 0.001). Blood pressure control was sustained but not further improved between 6 months and 2 years, with 66.5% controlled at 2 years following baseline. Higher initial systolic blood pressure, black race and hospitalization in the previous year were associated with higher likelihood of uncontrolled blood pressure at 6 months; whereas baseline cardiovascular disease, baseline dementia and later year of cohort entry were associated with lower likelihood of uncontrolled blood pressure.
We found an increase in blood pressure control in the 6 months following initiation of diabetes treatment. However, overall blood pressure control remained suboptimal and with no further improvement over the next 18 months.
确定新诊断糖尿病后 2 年内血压控制达标患者的比例。
本研究纳入了退伍军人事务部中南部网络中 2000 年至 2007 年间≥18 岁、高血压合并起始糖尿病药物治疗的退伍军人回顾性队列。比较糖尿病治疗起始时(基线)和 6、12、18 和 24 个月后血压控制情况。退伍军人事务部和美国糖尿病协会的控制标准分别为≤140/90mmHg 和≤130/80mmHg,分别为主要和次要结局。
在基线时,根据退伍军人事务部指南,16182 例患者中有 59.5%血压控制达标(31.5%采用美国糖尿病协会定义)。糖尿病治疗起始后 6 个月时,65.7%患者血压控制达标(P<0.001)。血压控制虽得以维持,但在 6 个月至 2 年内并未进一步改善,基线后 2 年时 66.5%患者血压控制达标。较高的初始收缩压、黑人种族和前一年住院与 6 个月时血压未控制的可能性增加相关;而基线心血管疾病、基线痴呆和队列入组后较晚年份与血压未控制的可能性降低相关。
我们发现,在起始糖尿病治疗后 6 个月内血压控制情况有所改善。然而,总体血压控制仍不理想,在接下来的 18 个月内无进一步改善。