婴儿体重和身长增长的 80 年趋势：费尔斯纵向研究。
Eighty-year trends in infant weight and length growth: the Fels Longitudinal Study.
机构信息
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
出版信息
J Pediatr. 2012 May;160(5):762-8. doi: 10.1016/j.jpeds.2011.11.002. Epub 2011 Dec 16.
OBJECTIVES
To investigate secular trends in weight and length growth from birth to 3 years of age in infants born from 1930 to 2008, and to assess whether these trends were associated with concurrent trends in pace of infant skeletal maturation and maternal body mass index.
STUDY DESIGN
Longitudinal weight and length data from 620 infants (302 girls) were analyzed with mixed effects modeling to produce growth curves and predicted anthropometry for infants born from 1930 to 1949, 1950 to 1969, 1970 to 1989, and 1990 to 2008.
RESULTS
The most pronounced differences in growth occurred in the first year of life. Infants born after 1970 were approximately 450 g heavier and 1.4 cm longer at birth, but demonstrated slower growth to 1 year of age than infants born before 1970. Growth trajectories converged after 1 year of age. There was no evidence that relative skeletal age, maternal body mass index, or maternal age together mediated associations between cohort and growth.
CONCLUSIONS
Recent birth cohorts may be characterized not only by greater birth size, but also by subsequent catch-down growth. Trends over time in human growth do not increase monotonically, and growth velocity in the first year may have declined compared with preceding generations.
目的
调查自 1930 年至 2008 年出生的婴儿从出生到 3 岁时体重和身长的增长趋势，并评估这些趋势是否与同期婴儿骨骼成熟速度和母亲体重指数的变化相关。
研究设计
对 620 名婴儿（302 名女孩）的纵向体重和身长数据进行混合效应模型分析，以生成 1930 年至 1949 年、1950 年至 1969 年、1970 年至 1989 年和 1990 年至 2008 年出生婴儿的生长曲线和预测体格。
结果
在生命的第一年，生长差异最为显著。1970 年后出生的婴儿出生时体重约增加 450 克，身长增加 1.4 厘米，但与 1970 年前出生的婴儿相比，1 岁前的生长速度较慢。1 岁后生长轨迹趋同。没有证据表明相对骨骼年龄、母亲体重指数或母亲年龄共同介导了队列和生长之间的关系。
结论
最近的出生队列不仅以更大的出生体重为特征，而且以随后的追赶生长为特征。人类生长的趋势并非单调递增，与前几代相比，第一年的生长速度可能有所下降。
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