Department of Pediatrics, University of Colorado, Denver, CO, USA.
J Pediatr. 2012 May;160(5):827-31.e1. doi: 10.1016/j.jpeds.2011.11.004. Epub 2011 Dec 16.
To assess the risk estimates for respiratory syncytial virus (RSV) hospitalization in children with Down syndrome (DS) and the clinical features and severity of RSV lower respiratory tract infection (LRTI) in hospitalized children.
Statewide hospitalization data for children with DS for 1995 through 2006 from the Colorado Health and Hospital Association database were combined with birth data from the Colorado Department of Public Health and Environment to obtain population-based estimates of RSV LRTI hospitalization for children with DS in the first 2 years of life. RSV hospitalization data for children with DS at the Children's Hospital Colorado for 2000 through 2006 were used to compare the course and severity of hospitalization of DS LRTI admissions with those of matched control subjects.
There were 85 RSV LRTI hospitalizations in 630 children born with DS in Colorado, with 50 having no concurrent underlying conditions identified. Children with DS had a significantly higher risk than did those without DS for being hospitalized with RSV LRTI (OR, 5.99; 95% CI, 6.68-5.38), even in the absence of other underlying conditions (OR 3.5; 95% CI, 3.10-4.12). In the case-control study, children with DS hospitalized for RSV presented more frequently with fever (P = .005), had consolidation reported more often on chest radiography (P = .003), and were given bronchodilator therapy more often during the hospital stay (P = .002).
Children with DS have a higher risk of being hospitalized with RSV LRTI even in the absence of coexisting risk factors. They present more often with fever and more often have radiographic consolidation detected on chest radiography.
评估唐氏综合征（Down syndrome，DS）患儿呼吸道合胞病毒（respiratory syncytial virus，RSV）住院的风险估计值，以及住院患儿 RSV 下呼吸道感染（lower respiratory tract infection，LRTI）的临床特征和严重程度。
将 1995 年至 2006 年期间科罗拉多州卫生与医院协会数据库中 DS 患儿的全州住院数据与科罗拉多州公共卫生与环境部的出生数据相结合，以获得 DS 患儿生命最初 2 年中 RSV LRTI 住院的基于人群的估计值。利用 2000 年至 2006 年科罗拉多儿童医院 DS 患儿的 RSV 住院数据，比较 DS LRTI 入院的住院过程和严重程度与匹配对照患儿的住院过程和严重程度。
在科罗拉多州出生的 630 名患有 DS 的儿童中，有 85 名患有 RSV LRTI，其中 50 名未发现其他合并症。与无 DS 的患儿相比，患有 DS 的患儿因 RSV LRTI 住院的风险显著更高（OR，5.99；95%CI，6.68-5.38），即使在无其他合并症的情况下（OR，3.5；95%CI，3.10-4.12）。在病例对照研究中，患有 DS 且因 RSV 住院的患儿更常出现发热（P =.005），胸部 X 线检查更常报告实变（P =.003），且在住院期间更常接受支气管扩张剂治疗（P =.002）。
即使不存在共存的危险因素，患有 DS 的患儿因 RSV LRTI 住院的风险也更高。他们更常出现发热，且更常出现胸部 X 线检查实变。
