University of Wrocław, Laboratory of Cytobiochemistry, Biotechnology Faculty, Przybyszewskiego 63-77, 51-148 Wrocław, Poland.
Eur J Cell Biol. 2012 Feb;91(2):107-17. doi: 10.1016/j.ejcb.2011.09.013. Epub 2011 Dec 16.
Palmitoylation is one of the most common posttranslational lipid modifications of proteins and we now know quite a lot about it. However, the state of knowledge about the enzymes that catalyze this process is clearly insufficient. This review is focused on 23 human DHHC genes and their products - protein palmitoyltransferases. Here we describe mainly the structure and function of these proteins, but also, to a lesser degree, what the substrates of the enzymes are and whether they are related to various diseases. The main aim of this review was to catalogue existing information concerning the human DHHC family of genes/proteins, making them and their functions easier to understand.
棕榈酰化是蛋白质最常见的翻译后脂质修饰之一，我们现在对此已经有了相当多的了解。然而，对于催化这一过程的酶的了解显然还不够。这篇综述主要集中在 23 个人类 DHHC 基因及其产物——蛋白质棕榈酰转移酶上。在这里，我们主要描述这些蛋白质的结构和功能，但也在较小程度上描述了这些酶的底物是什么，以及它们是否与各种疾病有关。本综述的主要目的是对人类 DHHC 基因/蛋白质家族的现有信息进行编目，使人们更容易理解它们及其功能。
