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Distinct palmitoylation of Foxp3 regulates the function of regulatory T cells via palmitoyltransferases.

作者信息

Zhou Binhui, Zhang Mengjie, Ma Haoyuan, Wang Ying, Qiu Juanjuan, Liu Yang, Lu Liaoxun, Li Tianhan, Zhang Lichen, Huang Rong, Gu Yanrong, Kong Eryan, Liang Yinming

机构信息

Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453003, China.

Laboratory of Mouse Genetics, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, 453003, China.

出版信息

Cell Mol Immunol. 2024 Jul;21(7):787-789. doi: 10.1038/s41423-024-01166-6. Epub 2024 May 8.

DOI:10.1038/s41423-024-01166-6
PMID:38720064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11214613/
Abstract
摘要

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本文引用的文献

1
The palmitoylation of AEG-1 dynamically modulates the progression of hepatocellular carcinoma.棕榈酰化的 AEG-1 动态调节肝细胞癌的进展。
Theranostics. 2022 Oct 3;12(16):6898-6914. doi: 10.7150/thno.78377. eCollection 2022.
2
Tumor-associated Tregs obstruct antitumor immunity by promoting T cell dysfunction and restricting clonal diversity in tumor-infiltrating CD8+ T cells.肿瘤相关调节性 T 细胞（Tregs）通过促进 T 细胞功能障碍和限制肿瘤浸润 CD8+T 细胞的克隆多样性来阻碍抗肿瘤免疫。
J Immunother Cancer. 2022 May;10(5). doi: 10.1136/jitc-2022-004605.
3
GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice.GFAP 过度棕榈酰化加剧了 PPT1 缺陷型小鼠的星形胶质细胞增生和神经退行性病变。
Proc Natl Acad Sci U S A. 2021 Mar 30;118(13). doi: 10.1073/pnas.2022261118.
4
FoxP3 T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets.FoxP3+ T 调节性细胞在癌症中的作用：预后生物标志物和治疗靶点。
Cancer Lett. 2020 Oct 10;490:174-185. doi: 10.1016/j.canlet.2020.07.022. Epub 2020 Jul 25.
5
The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation.去泛素化酶 USP44 通过防止 FOXP3 降解来促进炎症期间的 Treg 功能。
EMBO Rep. 2020 Sep 3;21(9):e50308. doi: 10.15252/embr.202050308. Epub 2020 Jul 9.
6
Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours.抑制 PD-L1 的棕榈酰化可增强 T 细胞对肿瘤的免疫反应。
Nat Biomed Eng. 2019 Apr;3(4):306-317. doi: 10.1038/s41551-019-0375-6. Epub 2019 Mar 25.
7
Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells.Nemo 样激酶驱动 Foxp3 稳定性，对调节性 T 细胞维持免疫耐受至关重要。
Cell Rep. 2019 Mar 26;26(13):3600-3612.e6. doi: 10.1016/j.celrep.2019.02.087.
8
TRAF6 directs FOXP3 localization and facilitates regulatory T-cell function through K63-linked ubiquitination.TRAF6 通过 K63 连接的泛素化指导 FOXP3 的定位并促进调节性 T 细胞的功能。
EMBO J. 2019 May 2;38(9). doi: 10.15252/embj.201899766. Epub 2019 Mar 18.
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Distinctive Surface Glycosylation Patterns Associated With Mouse and Human CD4 Regulatory T Cells and Their Suppressive Function.与小鼠和人类CD4调节性T细胞及其抑制功能相关的独特表面糖基化模式
Front Immunol. 2017 Aug 21;8:987. doi: 10.3389/fimmu.2017.00987. eCollection 2017.
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The transcriptional coactivator TAZ regulates reciprocal differentiation of T17 cells and T cells.转录共激活因子 TAZ 调节 T17 细胞和 T 细胞的相互分化。
Nat Immunol. 2017 Jul;18(7):800-812. doi: 10.1038/ni.3748. Epub 2017 May 15.