Department of Psychology, University of Delaware, USA.
Biol Psychol. 2012 Feb;89(2):387-97. doi: 10.1016/j.biopsycho.2011.12.001. Epub 2011 Dec 15.
In the current study, event-related potentials (ERPs) and behavioral responses were measured in individuals meeting diagnostic criteria for social phobia, depression, their combination, or neither in order to examine the unique and combined effects of social phobia and depression on the interpretation of ambiguous social scenarios. ERPs revealed a lack of positive interpretation bias and some suggestion of a negative bias in the semantic expectancy N4 component across all clinical groups. Furthermore, socially phobic and comorbid individuals showed reductions in baseline attention allocation to the task, as indexed by P6 amplitude. RT and accuracy likewise revealed a lack of positive interpretation bias across disordered groups. When considered on a continuum across all samples, social phobia and depression symptoms were related to the N4 interpretation bias effect whereas P6 amplitude reduction and RT interpretation bias appeared uniquely associated with social phobia.
在当前的研究中，我们测量了符合社交恐惧症、抑郁症、两者兼有或两者都不符合诊断标准的个体的事件相关电位（ERPs）和行为反应，以检验社交恐惧症和抑郁症对模糊社交场景的解释的独特和综合影响。ERPs 显示，在所有临床组中，语义预期 N4 成分缺乏积极的解释偏差，并且存在一些消极偏差的迹象。此外，社交恐惧症和共病个体的 P6 振幅表明，他们对任务的基线注意力分配减少。RT 和准确性也显示出所有障碍组缺乏积极的解释偏差。当考虑到所有样本的连续体时，社交恐惧症和抑郁症状与 N4 解释偏差效应有关，而 P6 振幅减小和 RT 解释偏差似乎与社交恐惧症有独特的关联。
