Dong-A University College of Medicine, Busan, Korea.
Acta Haematol. 2012;127(2):100-4. doi: 10.1159/000333113. Epub 2011 Dec 15.
Primary thyroid marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type (pTY-MZL) is an extremely uncommon form of lymphoma. Due to its rarity, the natural history and optimal treatment modality for this disease have yet to be clearly established.
A total of 27 patients with histologically confirmed pTY-MZL were retrospectively analyzed.
The median age of our subjects was 53 years (range 25-82). This study involved 17 females (63.0%) and 10 males (37.0%). Twenty-four out of 27 patients (88.9%) initially presented with localized disease, defined by Ann Arbor stage I/II. Bone marrow involvement was detected in 8.3% of the patients (2 patients), and 91.7% of the patients (25 of 27) were categorized into the low or low-intermediate risk group, according to the International Prognostic Index criteria. Accompanying Hashimoto's thyroiditis was detected in 72% of the patients, whereas thyroglobulin antibody levels were elevated in 70% of the patients. Twenty-six patients were treated with surgery, radiotherapy or chemotherapy, and 25 patients achieved complete remission. During the follow-up period, only 2 patients evidenced progression, and no deaths occurred over the course of the study.
pTY-MZL tends to be an indolent disease. However, unlike other mucosa-associated lymphoid tissue site MZLs, pTY-MZL was well controlled via several treatment modalities, and the patients' responses were sustained for a prolonged period.
黏膜相关淋巴组织型原发性甲状腺边缘区 B 细胞淋巴瘤（pTY-MZL）是一种极罕见的淋巴瘤。由于其罕见性，该病的自然病史和最佳治疗方式尚未明确。
回顾性分析了 27 例经组织学证实的 pTY-MZL 患者。
本研究对象的中位年龄为 53 岁（范围 25-82 岁）。本研究共纳入 17 例女性（63.0%）和 10 例男性（37.0%）。27 例患者中，24 例（88.9%）最初表现为局限性疾病，符合 Ann Arbor 分期 I/II 期。2 例（8.3%）患者骨髓受累，91.7%（25/27）的患者根据国际预后指数标准归入低危或低中危组。72%的患者伴有桥本甲状腺炎，70%的患者甲状腺球蛋白抗体水平升高。26 例患者接受了手术、放疗或化疗，25 例患者达到完全缓解。在随访期间，仅 2 例患者病情进展，研究过程中无死亡病例。
pTY-MZL 倾向于为惰性疾病。然而，与其他黏膜相关淋巴组织部位的 MZL 不同，pTY-MZL 可通过多种治疗方式得到很好的控制，且患者的缓解持续时间较长。
