Department of Internal Medicine, National Research Center, Cairo, Egypt.
Med Princ Pract. 2012;21(3):249-53. doi: 10.1159/000334588. Epub 2011 Dec 16.
To assess highly sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) as inflammatory biomarkers in patients with asymptomatic primary hyperparathyroidism (PHPT).
A total of 26 patients with asymptomatic PHPT and 22 age- and sex-matched individuals as a control group were recruited for the study. Corrected serum calcium, phosphorus, alkaline phosphatase, serum 25-hydroxyvitamin D, intact parathyroid hormone (PTH), hs-CRP and IL-6 were measured for all subjects.
Serum hs-CRP and IL-6 were significantly higher in asymptomatic PHPT patients than in the control group (hs-CRP: 4.15 ± 0.54 vs. 2.24 ± 0.11 mg/l; IL-6: 4.50 ± 0.80 vs. 2.56± 0.29 pg/ml; p < 0.001). Moreover, in asymptomatic PHPT patients, serum PTH was significantly correlated with hs-CRP and IL-6 (r = 0.820, p < 0.001 and r = 0.787, p < 0.001, respectively).
Inflammatory biomarkers were higher in patients with asymptomatic PHPT than in controls. Moreover, serum PTH was significantly correlated with inflammatory biomarkers which may suggest a subclinical inflammatory response in this group of patients.
评估高敏 C 反应蛋白（hs-CRP）和白细胞介素 6（IL-6）作为无症状原发性甲状旁腺功能亢进症（PHPT）患者的炎症生物标志物。
共招募了 26 例无症状 PHPT 患者和 22 名年龄和性别匹配的对照组个体作为研究对象。对所有受试者进行校正血清钙、磷、碱性磷酸酶、血清 25-羟维生素 D、全段甲状旁腺激素（PTH）、hs-CRP 和 IL-6 的检测。
无症状 PHPT 患者的血清 hs-CRP 和 IL-6 明显高于对照组（hs-CRP：4.15±0.54 vs. 2.24±0.11mg/l；IL-6：4.50±0.80 vs. 2.56±0.29pg/ml；p<0.001）。此外，在无症状 PHPT 患者中，血清 PTH 与 hs-CRP 和 IL-6 呈显著正相关（r=0.820，p<0.001 和 r=0.787，p<0.001）。
无症状 PHPT 患者的炎症标志物高于对照组。此外，血清 PTH 与炎症标志物显著相关，这表明该组患者存在亚临床炎症反应。
