Kathrani Aarti, Parkes Gina
Department of Clinical Science and Services, Royal Veterinary College, Hertfordshire AL9 7TA, UK.
Animals (Basel). 2022 Jun 20;12(12):1594. doi: 10.3390/ani12121594.
Modulen IBD is an enteral liquid diet that can induce remission rates similar to glucocorticoids in children with inflammatory bowel disease. The Modulen IBD liquid diet has not been previously investigated in dogs. Our study aimed to describe the use of the Modulen IBD liquid diet in hospitalized dogs with inflammatory protein-losing enteropathy (PLE), including its tolerance and effects on appetite and gastrointestinal signs, and laboratory parameters during hospitalization. Of the 14 dogs hospitalized for PLE that had an esophagostomy feeding tube placed at the time of endoscopy, 5 were eligible and prospectively enrolled. The Modulen IBD liquid diet was supplemented with whey powder isolate and a multivitamin/mineral blend to ensure the diet was complete and balanced for canine adult maintenance and had a macronutrient profile desirable for PLE. All five dogs tolerated tube feedings with the Modulen IBD liquid diet, allowing an increase of 75 to 100% of the resting energy requirement (RER) by day 3 to 4. The diet was administered without glucocorticoid in all five dogs. All five of these dogs had a resolution of anorexia allowing the voluntary intake of a commercial hydrolyzed protein diet prior to the use of glucocorticoids. Of these five dogs, three (60%) had stable or improved serum albumin concentrations (median % increase: 10.3, range: 0−31.1), four (80%) had improved or normalized serum globulin concentrations (median % increase: 12.9, range: 5.1−66.2) and four (80%) had improved or normalized serum cholesterol concentrations (median % increase: 31.5, range: 4.8−63) 2−3 days after initiating the diet. However, there were no significant differences in these selected biochemical parameters pre- and post-feeding with the diet (p > 0.080). In conclusion, the Modulen IBD liquid diet, fed via an esophagostomy feeding tube was well-tolerated in-hospital and resolved anorexia in all dogs and helped to improve selected biochemical parameters in some dogs. Further studies are needed to assess the long-term effects of feeding this diet on the rate of serum albumin increase and remission in dogs with inflammatory PLE.
Modulen IBD是一种肠内流食，在患有炎症性肠病的儿童中，其诱导缓解率与糖皮质激素相似。此前尚未对犬类进行过Modulen IBD流食的研究。我们的研究旨在描述Modulen IBD流食在患有炎症性蛋白丢失性肠病（PLE）的住院犬中的应用情况，包括其耐受性、对食欲和胃肠道症状的影响，以及住院期间的实验室参数。在内镜检查时放置了食管造口饲管的14只因PLE住院的犬中，有5只符合条件并被前瞻性纳入研究。Modulen IBD流食中添加了乳清分离蛋白粉和多种维生素/矿物质混合物，以确保该饮食对成年犬维持营养完整且均衡，并具有适合PLE的宏量营养素分布。所有5只犬都耐受了Modulen IBD流食的管饲，到第3至4天时，能量摄入量增加到静息能量需求（RER）的75%至100%。所有5只犬在喂食该饮食时均未使用糖皮质激素。所有这5只犬的厌食症状均得到缓解，在使用糖皮质激素之前能够自主摄入商业水解蛋白饮食。在这5只犬中，3只（60%）的血清白蛋白浓度稳定或升高（中位数升高百分比：10.3，范围：0 - 31.1），4只（80%）的血清球蛋白浓度升高或恢复正常（中位数升高百分比：12.9，范围：5.1 - 66.2），4只（80%）的血清胆固醇浓度升高或恢复正常（中位数升高百分比：31.5，范围：4.8 - 63），均在开始喂食该饮食2至3天后出现。然而，这些选定的生化参数在喂食该饮食前后无显著差异（p > 0.080）。总之，通过食管造口饲管喂食的Modulen IBD流食在住院犬中耐受性良好，所有犬的厌食症状均得到缓解，并且有助于改善部分犬的选定生化参数。需要进一步研究来评估喂食这种饮食对患有炎症性PLE的犬血清白蛋白升高率和缓解情况的长期影响。
