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本文引用的文献

1
Interactions between cancer stem cells and their niche govern metastatic colonization.癌症干细胞与其生态位之间的相互作用控制着转移定植。
Nature. 2011 Dec 7;481(7379):85-9. doi: 10.1038/nature10694.
2
Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis.血小板与癌细胞之间的直接信号转导诱导上皮-间充质样转化并促进转移。
Cancer Cell. 2011 Nov 15;20(5):576-90. doi: 10.1016/j.ccr.2011.09.009.
3
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.巨噬细胞与受体 VCAM-1 的结合在乳腺癌细胞向肺部浸润过程中传递存活信号。
Cancer Cell. 2011 Oct 18;20(4):538-49. doi: 10.1016/j.ccr.2011.08.025.
4
VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization.S100A4+ 基质细胞产生的 VEGF-A 和 Tenascin-C 对于转移定植是重要的。
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16002-7. doi: 10.1073/pnas.1109493108. Epub 2011 Sep 12.
5
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs.乳腺癌细胞产生 tenascin C 作为转移生态位组成部分以在肺部定植。
Nat Med. 2011 Jun 26;17(7):867-74. doi: 10.1038/nm.2379.
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The extracellular matrix: not just pretty fibrils.细胞外基质：不仅仅是漂亮的纤维。
Science. 2009 Nov 27;326(5957):1216-9. doi: 10.1126/science.1176009.
7
Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture.骨膜蛋白将 tenascin-C 纳入细胞外基质中，构成细胞外网格结构。
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Cancer micrometastases.癌症微转移灶
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Microenvironmental regulation of metastasis.转移的微环境调节
Nat Rev Cancer. 2009 Apr;9(4):239-52. doi: 10.1038/nrc2618. Epub 2008 Mar 12.
10
Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors.MMTV-Wnt-1 小鼠乳腺肿瘤中癌症干细胞的分离与分子特征分析
Stem Cells. 2008 Feb;26(2):364-71. doi: 10.1634/stemcells.2007-0440. Epub 2007 Nov 1.

转移灶细胞外基质成分。

Extracellular matrix players in metastatic niches.

机构信息

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany.

出版信息

EMBO J. 2012 Jan 18;31(2):254-6. doi: 10.1038/emboj.2011.469. Epub 2011 Dec 16.

DOI:10.1038/emboj.2011.469
PMID:22179697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3261570/
Abstract

Nature 481 7379, 85–89 (2012); published online December 07 2011 Metastatic niches support the survival and fitness of disseminated tumour cells (DTCs) in otherwise inhospitable tissue environments. The components of metastatic niches have remained a matter of conjecture, but recent reports, including one in a current issue of , point at the extracellular matrix (ECM) proteins periostin and tenascin C (TNC) as key metastatic niche molecules. By enhancing Wnt and Notch signalling in cancer cells, these proteins provide physical as well as signalling support for metastasis-initiating cells. These findings underscore the importance of the ECM environment in cancer and provide potential drug targets against metastasis.

摘要

自然 481 7379, 85–89 (2012); 在线发表 2011 年 12 月 07 日 转移龛支持在原本不适宜的组织环境中扩散的肿瘤细胞 (DTCs) 的存活和适应性。转移龛的组成部分一直是推测的问题，但最近的报告，包括本期中的一篇报告，指出细胞外基质 (ECM) 蛋白骨膜蛋白和 tenascin C (TNC) 是关键的转移龛分子。这些蛋白质通过增强癌细胞中的 Wnt 和 Notch 信号，为起始转移的细胞提供物理和信号支持。这些发现强调了 ECM 环境在癌症中的重要性，并为针对转移的潜在药物靶点提供了依据。