转移灶细胞外基质成分。
Extracellular matrix players in metastatic niches.
机构信息
Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany.
出版信息
EMBO J. 2012 Jan 18;31(2):254-6. doi: 10.1038/emboj.2011.469. Epub 2011 Dec 16.
Abstract
Nature 481 7379, 85–89 (2012); published online December 07 2011 Metastatic niches support the survival and fitness of disseminated tumour cells (DTCs) in otherwise inhospitable tissue environments. The components of metastatic niches have remained a matter of conjecture, but recent reports, including one in a current issue of , point at the extracellular matrix (ECM) proteins periostin and tenascin C (TNC) as key metastatic niche molecules. By enhancing Wnt and Notch signalling in cancer cells, these proteins provide physical as well as signalling support for metastasis-initiating cells. These findings underscore the importance of the ECM environment in cancer and provide potential drug targets against metastasis.
摘要
自然 481 7379, 85–89 (2012); 在线发表 2011 年 12 月 07 日 转移龛支持在原本不适宜的组织环境中扩散的肿瘤细胞 (DTCs) 的存活和适应性。转移龛的组成部分一直是推测的问题，但最近的报告，包括本期中的一篇报告，指出细胞外基质 (ECM) 蛋白骨膜蛋白和 tenascin C (TNC) 是关键的转移龛分子。这些蛋白质通过增强癌细胞中的 Wnt 和 Notch 信号，为起始转移的细胞提供物理和信号支持。这些发现强调了 ECM 环境在癌症中的重要性，并为针对转移的潜在药物靶点提供了依据。
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本文引用的文献
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VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization.S100A4+ 基质细胞产生的 VEGF-A 和 Tenascin-C 对于转移定植是重要的。
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