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内镜超声引导下肉毒杆菌毒素注射治疗贲门失弛缓症合并食管静脉曲张

Achalasia cardia with esophageal varix managed with endoscopic ultrasound-guided botulinum toxin injection.

作者信息

Lakhtakia Sandeep, Monga Amitabh, Gupta Rajesh, Kalpala Rakesh, Pratap Nitesh, Wee Eric, Arjunan Saravanan, Reddy D Nageshwar

机构信息

Asian Institute of Gastroenterology, Somajiguda, Hyderabad, India.

出版信息

Indian J Gastroenterol. 2011 Dec;30(6):277-9. doi: 10.1007/s12664-011-0149-x. Epub 2011 Dec 17.

Abstract

Achalasia cardia is a motility disorder of the esophagus characterized by failure of relaxation of the lower esophageal sphincter. Nitrates and calcium channel blockers, pneumatic dilatation, botulinum toxin injection and surgical myotomy have been described in literature as possible management options. We present a patient who presented with achalasia and was co-incidentally diagnosed to have cryptogenic cirrhosis with portal hypertension and had esophageal varices. This clinical combination precluded the use of pneumatic dilatation and surgical myotomy. We injected botulinum toxin into the lower esophageal sphincter using a celiac plexus neurolysis needle under endoscopic ultrasound guidance; the clinical response was good.

摘要

贲门失弛缓症是一种食管动力障碍性疾病,其特征为食管下括约肌松弛失败。硝酸盐类和钙通道阻滞剂、气囊扩张、肉毒杆菌毒素注射及手术肌切开术在文献中被描述为可能的治疗选择。我们报告一例贲门失弛缓症患者,该患者同时被诊断为隐源性肝硬化伴门静脉高压及食管静脉曲张。这种临床情况排除了气囊扩张和手术肌切开术的应用。我们在内镜超声引导下使用腹腔神经丛松解针将肉毒杆菌毒素注射到食管下括约肌;临床反应良好。

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